[HTML][HTML] The role of N-glycosylation in cancer

Y Lin, DM Lubman - Acta Pharmaceutica Sinica B, 2023 - Elsevier
… Aberrant N-glycosylation significantly impacts cancer processes and targeted therapies in …
the fundamental process of protein N-glycosylation and summarizes glycosylation changes in …

Advances in glycosylation-mediated cancer-targeted drug delivery

L Cai, Z Gu, J Zhong, D Wen, G Chen, L He, J Wu… - Drug discovery today, 2018 - Elsevier
… Monopoli and colleagues demonstrated that, after glycosylation, the glycol–protein corona
plays a … The modification of NPs with multi or full glycosylation would significantly impact the …

Glycosylation changes in brain cancer

L Veillon, C Fakih, H Abou-El-Hassan… - ACS chemical …, 2018 - ACS Publications
… subjected them to apoptosis, indicating the potential importance of A2G2F in targeted therapy.
(85) … The main focus of the study was to scrutinize the implication of changes in the glyco-…

Impact of protein glycosylation on the design of viral vaccines

K Schoen, B Lepenies… - Advances in …, 2021 - Springer
… , protein glycosylation is considered to be non-template driven, unlike the biosynthesis of
nucleic acids and peptides/proteins… Of all the types of protein glycosylation that exist [13], in this …

Using glyco-engineering to produce therapeutic proteins

M Dicker, R Strasser - Expert Opinion on Biological Therapy, 2015 - Taylor & Francis
… Thus, glycosylation has a huge impact on the biological … therapeutic efficacy. Dependent
on the species, cell-type, and physiological status of the production host, the glycosylation

Site-specific glycosylation analysis of epidermal growth factor receptor 2 (ErbB2): exploring structure and function toward therapeutic targeting

N Fujitani, Y Uehara, S Ariki, U Hashimoto… - …, 2024 - academic.oup.com
… the structural and functional implications of ErbB2 glycosylation and will contribute to
facilitating the establishment of glycan-targeted therapeutic strategies for ErbB2-positive cancers. …

CHO glycosylation mutants as potential host cells to produce therapeutic proteins with enhanced efficacy

P Zhang, KF Chan, R Haryadi, M Bardor… - Future Trends in …, 2013 - Springer
… The genetic defects in the glycosylation machinery in these cells … In light of the critical
impact of glycosylation on b … glycoprotein therapeutics with optimal glycosylation profiles, thus, …

Effects of glycosylation on the stability of protein pharmaceuticals

RJ Solá, KAI Griebenow - Journal of pharmaceutical sciences, 2009 - Elsevier
effect that glycans have in increasing the overall stability of glycoproteins, rational manipulation
of the glycosylation … vitro and in vivo stability of protein pharmaceuticals. The intent of this …

[HTML][HTML] Aberrant glycosylation and cancer biomarker discovery: a promising and thorny journey

M Wang, J Zhu, DM Lubman, C Gao - Clinical Chemistry and …, 2019 - degruyter.com
… and protein capture makes research on glycans and glycoproteins even more difficult,
thus resulting in sparse knowledge on the pathophysiological implications of glycosylation. …

Protein glycosylation: structural and functional aspects

H Lis, N Sharon - European journal of biochemistry, 1993 - Wiley Online Library
… of protein glycosylation is aided by the use of lectins and of antibodies to purified glycosylated
… Occasionally, the effect depends on the particular site of glycosylation within the protein …