Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment‐induced reduction in EGFR, p EGFR, and pSrc
A Jedlinski, S Garvin, AC Johansson… - Journal of Oral …, 2017 - Wiley Online Library
… Taken together, we demonstrate that high sensitivity to cetuximab was strongly associated
with treatment-induced reduction in EGFR and pEGFR both in vivo and in vitro in a panel of …
with treatment-induced reduction in EGFR and pEGFR both in vivo and in vitro in a panel of …
Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: Investigation of the role of cetuximab sensitivity and HPV status
H Baysal, I De Pauw, H Zaryouh, J De Waele… - British Journal of …, 2020 - nature.com
… However, further research is warranted to elucidate the mechanisms behind the reduced
ADCC within our cetuximab-sensitive cell lines compared to the acquired resistant and intrinsic …
ADCC within our cetuximab-sensitive cell lines compared to the acquired resistant and intrinsic …
Evaluation of individual sensitivity of head and neck squamous cell carcinoma to cetuximab by short‐term culture of tumor slices
M Peria, J Donnadieu, C Racz, JF Ikoli… - Head & …, 2016 - Wiley Online Library
… cetuximab significantly reduced cancer proliferation in slices prepared from 2 tumors, it had
no effect in slices from 1 tumor, and even induced … No significant reduction in proliferation …
no effect in slices from 1 tumor, and even induced … No significant reduction in proliferation …
A novel approach to predict cetuximab‐induced hypersensitivity reaction: detection of drug‐specific IgE on basophils
T Iwamoto, A Okamoto, H Ishinaga, K Shimizu… - Cancer …, 2016 - Wiley Online Library
… -IgE binding on basophils might be a more reliable predictor of HR in terms of reducing false…
development of more highly sensitive tests for predicting cetuximab-induced severe HR as …
development of more highly sensitive tests for predicting cetuximab-induced severe HR as …
The effects of cetuximab alone and in combination with radiation and/or chemotherapy in lung cancer
D Raben, B Helfrich, DC Chan, F Ciardiello… - Clinical Cancer …, 2005 - AACR
… Despite the cetuximab-induced increase in phosphorylation of EGFR and HER2, peak
EGF-induced levels of pEGFR and pHER2 were reduced by cetuximab in the cetuximab-sensitive …
EGF-induced levels of pEGFR and pHER2 were reduced by cetuximab in the cetuximab-sensitive …
Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance
M Rebucci, P Peixoto, A Dewitte… - International …, 2011 - spandidos-publications.com
… , reduce the downstream signaling pathways and induce EGFR … Cetuximab induces an
unexpected EGFR phosphorylation in … /AKT pathway restores sensitivity to cetuximab in HNSCC. …
unexpected EGFR phosphorylation in … /AKT pathway restores sensitivity to cetuximab in HNSCC. …
Cetuximab Resistance in Head and Neck Cancer Is Mediated by EGFR-K521 Polymorphism
F Braig, M Kriegs, M Voigtlaender, B Habel, T Grob… - Cancer research, 2017 - AACR
… reduced cetuximab efficacy. CetuGEX, an antibody with optimized Fc glycosylation targeting
the same epitope as cetuximab, restored HNSCC sensitivity … , we studied induction of ADCC …
the same epitope as cetuximab, restored HNSCC sensitivity … , we studied induction of ADCC …
The biological properties of cetuximab
… of EGFR mediated by cetuximab induces G1-phase cell … G1 arrest and apoptosis in DiFi
cells by bFGF was sensitive to … SCC exposed to cetuximab presented a reduction in the release …
cells by bFGF was sensitive to … SCC exposed to cetuximab presented a reduction in the release …
The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death
… Here we hypothesized that cetuximab induces immunogenic … cells, which are highly sensitive
to cetuximab 15 . These cells are … We found that 4μ8c strongly reduced XBP1s transcription …
to cetuximab 15 . These cells are … We found that 4μ8c strongly reduced XBP1s transcription …
Enhancement of cetuximab-induced radiosensitization by JAK-1 inhibition
JA Bonner, HQ Trummell, AB Bonner, CD Willey… - BMC cancer, 2015 - Springer
… cetuximab or 1 μM JAK1i for 8 or 24 h resulted in reduced activated STAT-3 (immunoblot),
and the combination treatment showed greater reduction … cetuximab sensitive and cetuximab …
and the combination treatment showed greater reduction … cetuximab sensitive and cetuximab …
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