Inhaled corticosteroids: potency, dose equivalence and therapeutic index

PT Daley‐Yates - British journal of clinical pharmacology, 2015 - Wiley Online Library
… and therapeutic index, and concludes that higher potency can potentially improve the
therapeutic index. … the relationship between inhaled corticosteroid potency and therapeutic index

Establishing a therapeutic index for the inhaled corticosteroids: part I: pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids

HW Kelly - Journal of allergy and clinical immunology, 1998 - Elsevier
The inhaled corticosteroids contain physicochemical differences that alter both glucocorticoid
receptor-binding characteristics and the pharmacokinetic variables of these drugs. …

Establishing a therapeutic index for the inhaled corticosteroids: Part II: Comparisons of systemic activity and safety among different inhaled corticosteroids

CA Sorkness - Journal of allergy and clinical immunology, 1998 - Elsevier
… that low to medium doses of inhaled corticosteroids do not cause cataracts or glaucoma.
Patients requiring high-dose inhaled corticosteroids should be monitored for adverse effects, …

Therapeutic index of inhaled corticosteroids in asthma: A dose–response comparison on airway hyperresponsiveness and adrenal axis suppression

P Daley‐Yates, N Brealey, S Thomas… - British Journal of …, 2021 - Wiley Online Library
… This study provides evidence that ICS may differ in their therapeutic index. When compared
at therapeutic doses, fluticasone furoate, with higher anti-inflammatory activity and greater …

Comparison of inhaled corticosteroids: an update

HW Kelly - Annals of Pharmacotherapy, 2009 - journals.sagepub.com
… of the inhaled corticosteroids have sufficient therapeutic indexes to provide similar efficacy
and safety in low to medium doses. Whether or not some of the newer inhaled corticosteroids

Dose response and therapeutic index of inhaled corticosteroids in asthma

P Högger - Current opinion in pulmonary medicine, 2003 - journals.lww.com
… can be concluded that FP has a favorable therapeutic index compared with BDP or BUD. No
therapeutic weight of the inhaled corticosteroids of the latest generation, MF and ciclesonide

Dose–response evaluation of the therapeutic index for inhaled budesonide in patients with mild-to-moderate asthma

AM Wilson, BJ Lipworth - The American journal of medicine, 2000 - Elsevier
… PURPOSE: Inhaled corticosteroids have beneficial effects on pulmonary function and … We
evaluated the therapeutic index of inhaled corticosteroids in asthmatic patients by comparing …

Assessment of therapeutic index of inhaled steroids

E Israel - The Lancet, 2000 - thelancet.com
Inhalation of corticosteroids enables the delivery of high concentrations of these agents to
… the therapeutic index of corticosteroids to such a degree that inhaled corticosteroids have …

[PDF][PDF] Comparing inhaled corticosteroids

GL Colice - Respiratory Care, 2000 - c.aarc.org
… understanding the therapeutic index of an inhaled corticosteroid. The therapeutic index
quantifies the … The concept of relative therapeutic indices is probably most easily understood by …

Intranasal corticosteroids: topical potency, systemic activity and therapeutic index

PT Daley-Yates, D Larenas-Linnemann… - Journal of asthma …, 2021 - Taylor & Francis
… for systemic adverse effects and an improved therapeutic index. It has been shown that …
multiple corticosteroid (CS) therapies could help reduce the total systemic burden of CS therapy. …