… This review highlights the beneficial role of IL-6 in addressing liver pathologies. … that IL-6
has a beneficial impact in numerous liver pathologies, due to its roles in liver regeneration and …

… how IL-6 pathways can be selectively inhibited and therapeutically exploited for the treatment
of liver pathologies. … Interleukin 6 (IL-6) signals via two distinct pathways on target cells. (A) …

… While a few studies suggest a pathological role for IL6 trans-signaling in the liver. IL11 is …
have very different roles in biology and pathology. In the liver, IL6R is mostly expressed on …

… a significant increase in expression of interleukin 6 (IL-6), a major … extent as that seen in the
livers of two common murine models of … from our pathology files 10 normal liver samples from …

… An important component of IL-6 signalling is that only restricted cells including liver … have
a mild phenotype with limited pathology demonstrating redundancy and overlapping functions. …

… histopathological liver change. Finally, no evidence of glomerular pathology was found.
Neutralising antibodies were detected within 10 days of rhIL-6 administration in all species. …

… interleukin (IL)-6 in inflammatory injury remains controversial. The present study elucidated
the role of IL-6 in liver … (LPS; 1 mg/kg) using IL-6 null (-/-) mice and corresponding wild-type (…

… of IL-6 in acute and chronic CCl4–induced liver injury and … IL-6 resulted in impaired liver
regeneration and increased liver … Treatment with IL-6 corrected these defects in IL-6/ livers and …

… 6 was considered to contribute to liver tumors. The complex function of IL-6 is involved in
class or trans-signaling in the liver… IL-6 trans-signaling in the treatment of liver pathologies still …

… car:dicJates that induce the pathological growth of mes~neial cells, I: … liver, but is dramatically
induced by IL-6 stimulation. In contrast, a drastic decrease of C/EBP mRNA level after IL-6 …