Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung

YT Kim, T Kim, DS Lee, SJ Park, J Park, SJ Seo… - Lung Cancer, 2008 - Elsevier
… clinical impact of EGFR mutation in patients with adenocarcinoma of the lung and who had
… predict the clinical outcomes of patients with lung adenocarcinoma after curative resection. …

Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation

K Suda, K Tomizawa, T Mitsudomi - Cancer and Metastasis Reviews, 2010 - Springer
… of KRAS mutations in lung cancer and contrast these with the features of EGFR mutations. …
Recent large-scale analysis of somatic mutations in lung adenocarcinoma also confirmed …

The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance

T Ohba, G Toyokawa, T Kometani, K Nosaki, F Hirai… - Surgery today, 2014 - Springer
EGFR mutations are detected in the lung adenocarcinomas of Japanese patients more …
frequency of EGFR mutations ranges from 40 to 60 % in Japanese lung adenocarcinomas [8…

Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features

KE Finberg, LV Sequist, VA Joshi, A Muzikansky… - The Journal of Molecular …, 2007 - Elsevier
… of EGFR mutation, we established that KRAS mutationsKRAS mutations with mucinous
BAC. Furthermore, multiple studies have suggested that EGFR mutations and KRAS mutations

Impact of KRAS and EGFR Gene Mutations on Recurrence and Survival in Patients with Surgically Resected Lung Adenocarcinomas

M Sonobe, M Kobayashi, M Ishikawa, R Kikuchi… - Annals of surgical …, 2012 - Springer
lung adenocarcinoma, and whose tumor harbored either KRAS codon 12 mutations or EGFR
gene mutationsKRAS codon 12 mutations and EGFR mutations were mutually exclusive. …

KRAS mutations in lung cancer

N Karachaliou, C Mayo, C Costa, I Magrí… - Clinical lung cancer, 2013 - Elsevier
Lung adenocarcinomas also harbor activating mutations in … oncogene (KRAS), and mutations
in EGFR and KRAS appear … of KRAS mutations, which varies from that of EGFR mutations. …

[HTML][HTML] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma

T Kosaka, Y Yatabe, R Onozato, H Kuwano… - Journal of Thoracic …, 2009 - Elsevier
… -TKIs or placebo).13, 14 However, we identified previously that EGFR mutations did not …
EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung adenocarcinomas

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

AM Unni, WW Lockwood, K Zejnullahu, SQ Lee-Lin… - Elife, 2015 - elifesciences.org
… -existing mutations of EGFR and KRAS in lung adenocarcinoma (Figure 1F). Likewise,
mutations in NF1, a suppressor of RAS activity, were negatively associated with EGFR mutations

[HTML][HTML] Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 …

A Yoshizawa, S Sumiyoshi, M Sonobe… - Journal of Thoracic …, 2013 - Elsevier
… classification of lung adenocarcinomas and EGFR and KRAS mutation status. … EGFR
mutations and 158 cases were examined for KRAS mutations, and the EGFR and KRAS mutations

[HTML][HTML] KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma

N Rekhtman, DC Ang, GJ Riely, M Ladanyi… - Modern Pathology, 2013 - Elsevier
… to EGFR-targeted therapies, and adverse prognosis. Whether KRAS-mutated lung
adenocarcinomas … We tested 180 resected lung adenocarcinomas for KRAS and EGFR mutations