Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung
… clinical impact of EGFR mutation in patients with adenocarcinoma of the lung and who had
… predict the clinical outcomes of patients with lung adenocarcinoma after curative resection. …
… predict the clinical outcomes of patients with lung adenocarcinoma after curative resection. …
Biological and clinical significance of KRAS mutations in lung cancer: an oncogenic driver that contrasts with EGFR mutation
K Suda, K Tomizawa, T Mitsudomi - Cancer and Metastasis Reviews, 2010 - Springer
… of KRAS mutations in lung cancer and contrast these with the features of EGFR mutations. …
Recent large-scale analysis of somatic mutations in lung adenocarcinoma also confirmed …
Recent large-scale analysis of somatic mutations in lung adenocarcinoma also confirmed …
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance
T Ohba, G Toyokawa, T Kometani, K Nosaki, F Hirai… - Surgery today, 2014 - Springer
… EGFR mutations are detected in the lung adenocarcinomas of Japanese patients more …
frequency of EGFR mutations ranges from 40 to 60 % in Japanese lung adenocarcinomas [8…
frequency of EGFR mutations ranges from 40 to 60 % in Japanese lung adenocarcinomas [8…
Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features
KE Finberg, LV Sequist, VA Joshi, A Muzikansky… - The Journal of Molecular …, 2007 - Elsevier
… of EGFR mutation, we established that KRAS mutations … KRAS mutations with mucinous
BAC. Furthermore, multiple studies have suggested that EGFR mutations and KRAS mutations …
BAC. Furthermore, multiple studies have suggested that EGFR mutations and KRAS mutations …
Impact of KRAS and EGFR Gene Mutations on Recurrence and Survival in Patients with Surgically Resected Lung Adenocarcinomas
M Sonobe, M Kobayashi, M Ishikawa, R Kikuchi… - Annals of surgical …, 2012 - Springer
… lung adenocarcinoma, and whose tumor harbored either KRAS codon 12 mutations or EGFR
gene mutations … KRAS codon 12 mutations and EGFR mutations were mutually exclusive. …
gene mutations … KRAS codon 12 mutations and EGFR mutations were mutually exclusive. …
KRAS mutations in lung cancer
N Karachaliou, C Mayo, C Costa, I Magrí… - Clinical lung cancer, 2013 - Elsevier
… Lung adenocarcinomas also harbor activating mutations in … oncogene (KRAS), and mutations
in EGFR and KRAS appear … of KRAS mutations, which varies from that of EGFR mutations. …
in EGFR and KRAS appear … of KRAS mutations, which varies from that of EGFR mutations. …
[HTML][HTML] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma
T Kosaka, Y Yatabe, R Onozato, H Kuwano… - Journal of Thoracic …, 2009 - Elsevier
… -TKIs or placebo).13, 14 However, we identified previously that EGFR mutations did not …
EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung adenocarcinomas …
EGFR, KRAS, and TP53 mutations among a large cohort of patients with lung adenocarcinomas …
Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma
AM Unni, WW Lockwood, K Zejnullahu, SQ Lee-Lin… - Elife, 2015 - elifesciences.org
… -existing mutations of EGFR and KRAS in lung adenocarcinoma (Figure 1F). Likewise,
mutations in NF1, a suppressor of RAS activity, were negatively associated with EGFR mutations …
mutations in NF1, a suppressor of RAS activity, were negatively associated with EGFR mutations …
[HTML][HTML] Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: analysis of 440 …
A Yoshizawa, S Sumiyoshi, M Sonobe… - Journal of Thoracic …, 2013 - Elsevier
… classification of lung adenocarcinomas and EGFR and KRAS mutation status. … EGFR
mutations and 158 cases were examined for KRAS mutations, and the EGFR and KRAS mutations …
mutations and 158 cases were examined for KRAS mutations, and the EGFR and KRAS mutations …
[HTML][HTML] KRAS mutations are associated with solid growth pattern and tumor-infiltrating leukocytes in lung adenocarcinoma
… to EGFR-targeted therapies, and adverse prognosis. Whether KRAS-mutated lung
adenocarcinomas … We tested 180 resected lung adenocarcinomas for KRAS and EGFR mutations …
adenocarcinomas … We tested 180 resected lung adenocarcinomas for KRAS and EGFR mutations …