High-fat diet causes lipotoxicity responses in cumulus–oocyte complexes and decreased fertilization rates
… -induced lipotoxicity in other cells, we hypothesized that obesity results in the activation of
lipotoxicity … , and apoptosis occur in ovarian cells and the oocyte in response to a high-fat diet. …
lipotoxicity … , and apoptosis occur in ovarian cells and the oocyte in response to a high-fat diet. …
Lipotoxicity: impact on oocyte quality and reproductive efficiency in mammals
JPM Alves, M Bertolini, LR Bertolini… - Animal …, 2018 - animal-reproduction.org
… granulosa cells and cumulus-oocyte complexes (COCs), which leads to a decrease in …
regard to the effects of lipotoxicity on oocyte quality. Lipotoxicity and reproductive response …
regard to the effects of lipotoxicity on oocyte quality. Lipotoxicity and reproductive response …
Proteomic changes in oocytes after in vitro maturation in lipotoxic conditions are different from those in cumulus cells
WFA Marei, G Van Raemdonck, G Baggerman… - Scientific reports, 2019 - nature.com
… cellular responses to PA-induced lipotoxicity during in … lipotoxic effects to reduce the number
of fixed factors, increase statistical power and allow accurate interpretation of the complex …
of fixed factors, increase statistical power and allow accurate interpretation of the complex …
[HTML][HTML] Exposure to lipid-rich follicular fluid is associated with endoplasmic reticulum stress and impaired oocyte maturation in cumulus-oocyte complexes
… lipotoxicity responses. It is likely that the observed changes in gene expression reflect alterations
in cumulus cells, as oocytes are … reticulum stress responses are occurring in the oocyte, …
in cumulus cells, as oocytes are … reticulum stress responses are occurring in the oocyte, …
Obesity on increases lipid droplets and lipotoxicity responses in the periovulatory cumulus-oocyte-complex
… High fat diet in mice and obesity in women increases oocyte lipid and induces lipotoxicity
responses that could contribute to their impaired oocyte developmental competence. …
responses that could contribute to their impaired oocyte developmental competence. …
The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity
F Lolicato, JF Brouwers, CHA de Lest… - Biology of …, 2015 - academic.oup.com
… involved in lipotoxic effects induced by saturated FA exposure of cumulus-oocyte complexes
(… intermediate responses when compared to control oocytes and to oocytes exposed to the …
(… intermediate responses when compared to control oocytes and to oocytes exposed to the …
The impact of obesity on oocytes: evidence for lipotoxicity mechanisms
… In other tissues, obesity leads to lipotoxicity responses including … lipotoxicity occurs in the
cumulus–oocyte complexes of obese mice and in the ovarian cells of women. Thus lipotoxicity …
cumulus–oocyte complexes of obese mice and in the ovarian cells of women. Thus lipotoxicity …
Cellular stress responses in oocytes: Molecular changes and clinical implications
WFA Marei, JLMR Leroy - … Biology and Translational Medicine, Volume 16 …, 2021 - Springer
… by which oocytes can sense and respond to stress are not … due to lipotoxicity, oxidative
stress, and heat stress on oocyte … mechanisms in whole cumulus-oocyte complexes (COCs) can …
stress, and heat stress on oocyte … mechanisms in whole cumulus-oocyte complexes (COCs) can …
Endoplasmic reticulum (ER) stress in cumulus-oocyte complexes impairs pentraxin-3 secretion, mitochondrial membrane potential (ΔΨm), and embryo development
… and oocyte quality in association with lipotoxicity responses in cumulus-oocyte complexes
(… intracellular lipid accumulation and altered mitochondrial activity in oocytes (16, 17), as well …
(… intracellular lipid accumulation and altered mitochondrial activity in oocytes (16, 17), as well …
Hyperglycaemia and lipid differentially impair mouse oocyte developmental competence
… exposed mouse cumulus–oocyte complexes to hyperglycaemia (… A biomarker of lipotoxicity
is ER stress, characterised by the … A dose–response experiment was performed to determine …
is ER stress, characterised by the … A dose–response experiment was performed to determine …
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