… obtain high-quality protein crystals. We previously found that protein crystals can be forcibly
… and have succeeded in crystallizing soluble and membrane proteins. The mechanism of this …

… So controlling protein nucleation may be an alternative … can induce protein crystallization
and improve crystal quality, so … local supersaturation, which favors nucleation and crystal …

… , both nucleation and growth of protein crystals proceed substantially more … a locally
increased chemical potential and lower slope of the growth hillocks on faces of the protein crystals, …

… If there is already a hydrophobic/hydrophilic surface in the system this will decrease the
work required to create critical nuclei and will increase locally the probability of nucleation with …

… model predicts an initial densification step followed by a local increase in crystallinity. Not
surprisingly, experimental observations of mesoscopic clusters have been linked to …

… The decrease in the nucleation energy barrier is calculated, … of porous materials for
nucleation of protein crystals, and will … , leading to a local increase in protein concentration. The …

… that the protein should be in the metastable phase for crystal growth, but for nucleation
higher levels of … If an environment can be created that favours a higher local concentration of …

… Phase diagrams can guideoptimization of conditions for nucleation and subsequent crystal
growth… The greater the number andcloseness in energy of these local minima, the greater the …

… from the last 150 years of protein crystal-growth experience. It contains descriptions of the
… serve to concentrate the protein locally and provide an interface for nucleation to occur. This …

… structural property of the MIP on the nucleation and growth of the two-step nucleation mechanism.
… of the MIP in the early stage of crystallization, ie there appears a local maximum in the …