… evidence suggests that numerous drugs and potentially toxic … drug metabolising enzymes
in olfactory mucosa, olfactory bulb and brain, which should constitute a CNS metabolic …

… Individual CYP expression is heterogeneous in the mammalian brain, with mRNA, protein,
and catalytic activity concentrated within specific brain structures, cell types, and subcellular …

… with the ontogeny of ATP metabolism, placing special emphasis on variations that occur
during development in different brain regions and across the mammalian species. It correlates …

… brain enzyme, as well as the one present in the liver, is inhibited by all the major classes of
nonsteroidal antiinflammatory drugs … neurotransmitter of the mammalian brain, that GABA A …

… brain, the liability of CNS drugs to cause CNS side effects, and the requirement of CNS drugs
to cross the blood-brain … , along with pharmacokinetics and drug metabolism, in the process …

… Although the main site for P450 dependent drug metabolism in humans and mammals is …
of the brain. Table 1 summarizes the P450s reported in human and rodent brain. The function …

… Drug metabolism in in vitro organotypic and cellular models of mammalian central nervous
system: activities of membrane-bound epoxide hydrolase and NADPH-cytochrome P-450 (c) …

… its inhibition by other drugs. This reaction is inhibited by the usual inhibitors of drug metabolism
such as SKF-525A [29], but is also inhibited by a range of antidepressant drugs including …

… All drugs used in this work appeared to be without effect on the substance … brain. This was
so in spite of the fact that some ofthese drugs (ether, /3-Tetra and insulin) cause a fall in brain …

… Targeted interventions with such specific 'kynurenergic' drugs can now be used to influence
brain physiology. This approach is also envisaged to normalize pathophysiologically …