… Medullary thyroid carcinoma is a rare malignant tumor originating in parafollicular C cells. It
accounts for 5 to 8% of all thyroid … the involvement of the RET proto-oncogene in hereditary …

… Mutations activate RET in a constitutive fashion which, in turn, results in aberrant stimulation
… RET in preclinical models of medullary thyroid carcinoma, and these models show that RET …

… the different RET mutations, we found 76.5% of RET 918 positive patients and 43% of RET
634 positive patients having nodes metastases. At variance, only 27% of RET negative cases …

… RET point mutation has been identified as a driver of tumorigenesis in medullary thyroid
carcinoma … in all cases of hereditary medullary thyroid carcinoma (MTC) and approximately 40% …

… medullary thyroid carcinoma (MTC). In this study, we aimed at investigating the prognostic
value of RET … Overall, the presence of RET mutation was associated with an elevated risk for …

… RET polymorphisms, we also investigated the role of a few other low-penetrance alleles of
genes involved in the RET … such RET variants and to improve our knowledge on the disease. …

… Hereditary medullary thyroid carcinoma (MTC) is caused by autosomal dominant gain-of-function
mutations in the RET proto-oncogene. Associations between specific RET mutations (…

… Sporadic medullary thyroid carcinomas (MTC) frequently harbor mutations in the RET …
a series of 51 sporadic MTC with 64.7% of RET-positive and 35.3% of RET-negative cases. …

… Correlation of mutation profiles and clinical outcomes in advanced and metastatic medullary
thyroid carcinomas. (A) The presence of a double RET mutation was significantly correlated …

… the RET protooncogene in sporadic medullary thyroid carcinoma. Genes Chromosom. Cancer
… mutations and allele loss at the RET locus in sporadic medullary thyroid carcinoma. Jpn. J…