… The microphthalmia transcription factor MITF plays a pivotal role in the development and …
in human melanoma. We found that MITF-M is repressed in 8 of 14 established melanoma cell …

… histopathological marker for melanoma, Mitf expression was examined in histologically
confirmed human melanoma specimens. Western blot analysis of melanoma cell lines revealed …

▪ Abstract The first mouse microphthalmia transcription factor (Mitf ) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

… transcription in the 501mel human melanoma … human melanoma cell lines. MITF recruits
RBPJK as a cofactor in repressing transcription of microRNAs miR-221 and miR-222 in human …

… Microphthalmia-associated transcription factor has been … melanoma, being expressed in
all nevi studied and between 88% and 100% of primary and metastatic epithelioid melanoma ( 7…

… pigment formation is mediated by the microphthalmia transcription factor, which is also critical
… isoform of microphthalmia transcription factor is lost in a subset of human melanoma cell …

… A significant fraction of primary human melanomas … melanomas without excessive quantities
of β-catenin in the nucleus. Ectopic expression of β-catenin in these human melanoma lines …

… revealed that Microphthalmia transcription factor protein (Mitf) … of Mitf is regulated as a
transcriptional target of β-catenin/Wnt … aberrantly in a substantial fraction of human melanomas. …

… melanoma is an aggressive cancer known for its notorious resistance to most current therapies.
The basic helix-loop-helix microphthalmia transcription factor (… of human melanoma cells …

… The C5 Ab recognizes mouse and human Mitf, whereas the D5 Ab recognizes only human
Mitf.20 In a recent study, King et al.20 reported that all of 76 human melanoma surgical …