Identification of a melanocyte-type promoter of the microphthalmia-associated transcription factor gene

N Fuse, K Yasumoto, H Suzuki, K Takahashi… - Biochemical and …, 1996 - Elsevier
… It is therefore conceivable that MITF is a transcription factor involved in … MITF gene contains
the two types of promoters, although it was reported that the protein-coding region of the MITF

Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas

S Giuliano, Y Cheli, M Ohanna, C Bonet, L Beuret… - Cancer research, 2010 - AACR
Microphthalmia-associated transcription factor (MITF), in which its M transcript is specifically
expressed in melanocyte cells, plays a critical role in melanoma proliferation, and its …

Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport

C Chiaverini, L Beuret, E Flori, P Abbe, K Bille… - Journal of Biological …, 2008 - ASBMB
… In this study, we show that microphthalmia-associated transcription factor (MITF) silencing
induces melanosome gathering around the nucleus and causes the relocalization of Rab27A, …

Regulation of the microphthalmia-associated transcription factor gene by the Waardenburg syndrome type 4 gene, SOX10

C Verastegui, K Bille, JP Ortonne, R Ballotti - Journal of Biological …, 2000 - ASBMB
… Mutations, which impair MITF function or … transcription factor Pax3, which regulates MITF
expression. Recently, mutations in SOX10, a gene encoding a SRY-related transcription factor, …

Microphthalmia transcription factor: a sensitive and specific melanocyte marker for melanoma diagnosis

R King, KN Weilbaecher, G McGill, E Cooley… - The American journal of …, 1999 - Elsevier
Microphthalmia transcription factor (Mitf) is a melanocytic nuclear protein critical for the
embryonic development and postnatal viability of melanocytes. It serves as a master regulator in …

Microphthalmia transcription factor induces both retinal pigmented epithelium and neural crest melanocytes from neuroretina cells

N Planque, G Raposo, L Leconte, O Anezo… - Journal of Biological …, 2004 - ASBMB
… is a downstream factor or a master regulator of melanocyte differentiation. To further study
the role of Mitf in committing cells to the melanocyte lineage, we express Mitf in the cultured …

… -specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1

H Saito, K Yasumoto, K Takeda, K Takahashi… - Journal of Biological …, 2002 - ASBMB
… encoding microphthalmia-associated transcription factor (MITF) … Melanocyte-specific MITF
isoform (MITF-M) is essential for … Here we show that MITF-M transactivates its own promoter (…

Microphthalmia‐associated transcription factor expression levels in melanoma cells contribute to cell invasion and proliferation

J Vachtenheim, L Ondrušová - Experimental dermatology, 2015 - Wiley Online Library
… with microphthalmia-associated transcription factor (MITF) expression in melanoma. The very
low MITF … cell-like properties, and high MITF levels promote proliferation and differentiation. …

Gene expression profiling identifies microphthalmia-associated transcription factor (MITF) and Dickkopf-1 (DKK1) as regulators of microenvironment-driven alterations …

ML Hartman, B Talar, MZ Noman… - PLoS …, 2014 - journals.plos.org
… The enhanced activity of MITF in melanospheres, as illustrated by the increased expression
of 74 MITF-dependent genes, identified MITF as a central transcriptional regulator in …

The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia‐associated transcription factor (MITF) and other melanogenesis‐related proteins in …

S Lu, A Slominski, SE Yang, C Sheehan… - Journal of cutaneous …, 2010 - Wiley Online Library
transcription factor MITF (microphthalmia-associated transcription factor). For the most part,
… the essential melanocyte transcription factor MITF (microphthalmia-associated transcription …