DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells

MS Roost, RC Slieker, M Bialecka, L Van Iperen… - Nature …, 2017 - nature.com
DNA methylation patterns are highly dynamic between week 9 (W9) and W22 of gestation.
We investigate the impact of reprogramming on organ-specific DNA methylation … that mouse

Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos

F Wang, Z Kou, Y Zhang, S Gao - Biology of reproduction, 2007 - academic.oup.com
methylated and undergoes passive DNA demethylation following embryo development [3,
7]. However, the mechanism of this asymmetric reprogramming of DNA methylation in … DNA

Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos

W Dean, F Santos, M Stojkovic… - Proceedings of the …, 2001 - National Acad Sciences
… A similar reprogramming cycle occurs in mouse … some DNA sequences were more highly
methylated in cloned versus normal morulae. Here we show that methylation reprogramming is …

DNA methylation and hydroxymethylation in stem cells

Y Cheng, N Xie, P Jin, T Wang - Cell biochemistry and function, 2015 - Wiley Online Library
… If the loss of DNA methylation at pluripotent genes is not achieved, cells will be only …
reprogrammed.23 Low-passage mouse and human iPSCs harbour residual DNA methylation ‘…

Programming and inheritance of parental DNA methylomes in mammals

L Wang, J Zhang, J Duan, X Gao, W Zhu, X Lu, L Yang… - Cell, 2014 - cell.com
… Additionally, very little is known about the DNA methylation … current knowledge on methylation
reprogramming in mammals … mice, and identified about 4.4 million SNPs. We collected …

DNA methylation programming and reprogramming in primate embryonic stem cells

NM Cohen, V Dighe, G Landan, S Reynisdottir… - Genome …, 2009 - genome.cshlp.org
DNA methylation is an important epigenetic mechanism, affecting normal development and …
reprogramming epigenomes during stem cell derivation. Here we report on DNA methylation

[HTML][HTML] DNA demethylation, Tet proteins and 5-hydroxymethylcytosine in epigenetic reprogramming: an emerging complex story

PWS Hill, R Amouroux, P Hajkova - Genomics, 2014 - Elsevier
… of reprogramming events, and understanding DNA methylation … potential drivers of epigenetic
reprogramming. Although some of … Moreover, Tet1 KO and Tet1/2 DKO mice have a fertility …

DNA methylation dynamics of the human preimplantation embryo

ZD Smith, MM Chan, KC Humm, R Karnik… - Nature, 2014 - nature.com
… may regulate global versus targeted reprogramming 15 . … with a methylation difference >0.1
between mouse ICM and mousemouse ICM if its methylation level is more similar to mouse

[HTML][HTML] Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice

Y Seki, K Hayashi, K Itoh, M Mizugaki, M Saitou… - Developmental …, 2005 - Elsevier
… within mouse centromeres and the SINES. To analyze genome-wide DNA methylation changes
… 2Aa,e), indicating that the genome-wide DNA methylation level is comparable between …

Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

AC Planello, J Ji, V Sharma, R Singhania, F Mbabaali… - Cell regeneration, 2014 - Springer
… (a DNA methylation inhibitor) increase reprogramming efficiency suggesting that the resistance
of somatic cell chromatin to remodeling is a barrier to reprogramming [… by reprogramming