Local geometry and evolutionary conservation of protein surfaces reveal the multiple recognition patches in protein-protein interactions
E Laine, A Carbone - PLoS computational biology, 2015 - journals.plos.org
… it predicts interacting residues that form recognition patches, it gives insights into the origins
of these patches and it enables to contrast the different properties of the interacting residues …
of these patches and it enables to contrast the different properties of the interacting residues …
Dissecting protein–protein recognition sites
P Chakrabarti, J Janin - Proteins: Structure, Function, and …, 2002 - Wiley Online Library
… The presence of two recognition patches at the antibody-combining sites is a consequence
of the clustering procedure, which we ran separately on the heavy and light chains. The …
of the clustering procedure, which we ran separately on the heavy and light chains. The …
Prediction of protein-protein interaction sites using patch analysis
S Jones, JM Thornton - Journal of molecular biology, 1997 - Elsevier
… here, is the identification of putative interaction sites upon the … protein, known to be involved
in protein-protein interactions, but … any two patches in the set of three was ⩾50% then the two …
in protein-protein interactions, but … any two patches in the set of three was ⩾50% then the two …
Analysis of protein-protein interaction sites using surface patches
S Jones, JM Thornton - Journal of molecular biology, 1997 - Elsevier
… to compare how such interaction patches differ from other sites on the protein surface. To …
recognition site requires largely polar interactions and hence the interface between the two …
recognition site requires largely polar interactions and hence the interface between the two …
Principles of protein− protein interactions: what are the preferred ways for proteins to interact?
… of protein−protein interactions, we can map cellular pathways and their intricate cross-connectivity
(eg, refs 7−11). Since two protein … Identification of protein−protein interactions is at the …
(eg, refs 7−11). Since two protein … Identification of protein−protein interactions is at the …
Prediction‐based fingerprints of protein–protein interactions
… recognition of protein–protein interaction sites in the case when the structure of an isolated
… literature, we also used two sets of complexes and interaction interfaces developed before by …
… literature, we also used two sets of complexes and interaction interfaces developed before by …
Prediction of protein‐protein interactions based on surface patch comparison
O Carugo, G Franzot - Proteomics, 2004 - Wiley Online Library
… of the two proteins, the interaction of which … protein-protein recognition while large patches
might contain a rather high fraction of atoms that are outside the protein-protein interaction …
might contain a rather high fraction of atoms that are outside the protein-protein interaction …
Identification of protein–protein interaction sites from docking energy landscapes
J Fernandez-Recio, M Totrov, R Abagyan - Journal of molecular biology, 2004 - Elsevier
… Interestingly, we found a six residue high-propensity binding patch in the ligand, located
correctly (83% accuracy) in one of the two experimental ligand interaction sites: indeed the one …
correctly (83% accuracy) in one of the two experimental ligand interaction sites: indeed the one …
Prediction of protein–protein interaction sites using patch-based residue characterization
Z Qiu, X Wang - Journal of theoretical biology, 2012 - Elsevier
… Using this patch-based model, we define different interacting … , there are two predicted
targets: residues and patches. Most … Two datasets are used to validate our method and directly …
targets: residues and patches. Most … Two datasets are used to validate our method and directly …
Drugs targeting protein–protein interactions
P Chène - ChemMedChem: Chemistry Enabling Drug …, 2006 - Wiley Online Library
… For interfaces with multiple recognition patches, one patch is generally larger and has a …
found in single-patch interfaces. The presence of recognition patches at protein interfaces is …
found in single-patch interfaces. The presence of recognition patches at protein interfaces is …
相关搜索
- multiple recognition patches protein surfaces
- protein protein interaction site predictions
- principles of protein protein interactions
- inhibitors of protein protein interactions
- visual analysis protein protein interactions
- druggability prediction protein protein interactions
- computational classification methods protein interaction prediction
- energy funnels protein protein recognition
- identification of protein protein interfaces
- contact matrix protein interaction
- protein interactions detailed atlas
- protein interactions complex networks
- protein interactions signature products
- protein interactions mechanisms and modification
- protein interactions rational design
- protein interactions feasibility study