… , crystallography, or fragment-based design equip multitarget compound development
with valuable tools. In this Perspective, we analyze the relevance of multiple ligands in drug …

The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews and …

… different approaches to multitarget therapy. … compounds produced by medicinal chemists
were screened by in vivo pharmacologists in whole animal models of disease. This approach …

… While medicinal chemists usually rely on some version of the lock and key paradigm to … to
compounds with unfavorable biopharmaceutic or pharmacokinetic profile (eg, compounds that …

… approach and related chemoinformatic methods application are described in comprehensive
overview about the development of tacrine- and donepezil-like multitarget compounds for …

… target-specific drugs are discussed including the rationale, the ‘master key compound’
concept and safety panels to address the possible unwanted effects of drugs multi-targeting. The …

… updated review of molecular hybridization and multitarget profiling (a rational drug design
approach), and its applications to the design and discovery of novel hybrid compounds with …

… This allows for identification of synergistic effects of multiple small molecules and ligands
to design a single multitarget compound from them. All these techniques still have a long way …

… Compound 3 was reported as a new multitarget therapeutic candidate, which incorporated
the … This work identified a novel approach to design multitarget drugs with pharmacophores …

… A major advantage of the screening approach is that it provides a compound that already …
the fact that starting compounds obtained via screening already possess multitarget activity, so …