Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning
… scanning, which combines saturation mutagenesis and next-generation sequencing (30).
Previous studies have applied deep mutational scanning … Although deep mutational scanning …
Previous studies have applied deep mutational scanning … Although deep mutational scanning …
Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning
AC Leonard, JJ Weinstein, PJ Steiner… - … design and selection, 2022 - academic.oup.com
… Illumina sequencing, the mutagenic library was divided into 2 … prepared by separate nicking
mutagenesis reactions. Library … To screen the core residue mutagenic library for protease-…
mutagenesis reactions. Library … To screen the core residue mutagenic library for protease-…
Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype
R Kugathasan, K Sukhova, M Moshe, P Kellam… - PLoS …, 2023 - journals.plos.org
… This study uses deep mutagenesis scanning with whole trimeric spike displayed on
mammalian cells to screen for mutations that increase ACE2 binding and escape antibodies. We …
mammalian cells to screen for mutations that increase ACE2 binding and escape antibodies. We …
[HTML][HTML] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
… The entry receptor for both SARS-CoV-2 and the original SARS-CoV (which we refer to
here as SARS-CoV-1) is the human cell-surface protein angiotensin converting enzyme 2 (ACE2)…
here as SARS-CoV-1) is the human cell-surface protein angiotensin converting enzyme 2 (ACE2)…
Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community
E Procko - Expert review of proteomics, 2020 - Taylor & Francis
… Deep mutagenesis or deep mutational scanning take advantage of next-generation …
prominent studies of SARS coronavirus 2 (SARS-CoV-2) have used deep mutagenesis to address …
prominent studies of SARS coronavirus 2 (SARS-CoV-2) have used deep mutagenesis to address …
In silico mutagenesis-based remodelling of SARS-CoV-1 peptide (ATLQAIAS) to inhibit SARS-CoV-2: structural-dynamics and free energy calculations
A Khan, S Umbreen, A Hameed, R Fatima… - Interdisciplinary …, 2021 - Springer
… mutagenesis-based remodeling of SARs-CoV-1 peptide (ATLQAIAS) was performed to inhibit
the activities of 3CLpro of SARS-CoV… this alanine scanning mutagenesis and residue scan …
the activities of 3CLpro of SARS-CoV… this alanine scanning mutagenesis and residue scan …
Computational mutagenesis at the SARS-CoV-2 spike protein/angiotensin-converting enzyme 2 binding interface: comparison with experimental evidence
… domain of SARS-CoV-2 (S-RBD CoV-2 ) showing the hot-spot residues at the protein/protein
binding interface as identified in our previous computational alanine scanning study. (25) …
binding interface as identified in our previous computational alanine scanning study. (25) …
[HTML][HTML] Serine-scanning mutagenesis studies of the C-terminal heptad repeats in the SARS coronavirus S glycoprotein highlight the important role of the short helical …
KE Follis, J York, JH Nunberg - Virology, 2005 - Elsevier
… The fusion subunit of the SARS-CoV S glycoprotein contains two regions of hydrophobic …
serine-scanning mutagenesis to the C-terminal-most heptad-repeat region in the SARS-CoV S …
serine-scanning mutagenesis to the C-terminal-most heptad-repeat region in the SARS-CoV S …
[HTML][HTML] Deep mutational scanning identifies SARS-CoV-2 Nucleocapsid escape mutations of currently available rapid antigen tests
… Experimental epitope mapping approaches use structure determination, site-directed
mutagenesis such as alanine-scanning, peptide arrays, and/or mass spectrometry. Each technique …
mutagenesis such as alanine-scanning, peptide arrays, and/or mass spectrometry. Each technique …
Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry
J Corver, R Broer, P van Kasteren, W Spaan - Virology journal, 2009 - Springer
… The TMD of the SARS CoV spike protein consists of three … extensive mutagenesis study of
the aromatic domain of SARS CoV … TMD are crucial for membrane fusion activity of SARS CoV. …
the aromatic domain of SARS CoV … TMD are crucial for membrane fusion activity of SARS CoV. …
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