… ocular drug development, safety assessment, ocular immunology, anatomy and physiology,
and examples of toxicology and drug… for ocular toxicity studies using the same ocular route of …

… , drug precipitation, and corneal toxicity. It is possible that different factors may contribute to
eye toxicity, … An ophthalmic baseline examination before anticancer treatment and careful …

… nor recommend for prospective ocular safety testing test in replacement of … toxicity testing
method as an alternative eye toxicity test. Ocular organotypic models or the enucleated eye test …

… ocular studies conducted earlier in drug development or any other nonclinical study types
conducted. Ocular toxicity … for ocular toxicity studies is that the level of evaluation should be …

… improve upon current approaches to clinical evaluation and semiquantitative scoring in the
… modern ocular drug development, we present herein the semiquantitative preclinical ocular …

… drug development programs, this review identifies noteworthy limitations of the most commonly
used ocular … in modern preclinical drug and device safety evaluation (summarized in …

… Many laboratories are currently developing skin organ culture models to assess dermal … in
vitro test systems have been developed as potential replacements for ocular toxicity testing in …

… Index of Side Effects: The lists of adverse ocular side effects due to preparations are …
importance not only in drug development, but also when applying a drug. Exact understanding of …

… evaluation of ocular toxicity, while Chapter 12 will review the use of nanoparticles for drug and
gene therapy of the eye… assessment of ocular drugs and devices, study design, and routes …

… inflammatory diseases as well as the first study to evaluate the eye toxicity of such … in vivo
Draize test were performed to evaluate the ocular compatibility of the formulations developed. …