Polycystic ovary syndrome: the epigenetics behind the disease

MC Eiras, DP Pinheiro, KAM Romcy, RA Ferriani… - Reproductive …, 2022 - Springer
… etiology of this syndrome [11]. This suggests a complex and multifactorial origin of PCOS,
in which genetic alterations, environmental factors, and epigenetic modifications contribute to …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
… Besides summarizing the genetic factors linked to PCOS, we highlight epigenetic
modulation as a mechanism that bridges early-life exposures and subsequent phenotypes in …

Modulation of the inflammatory response in polycystic ovary syndrome (PCOS)—searching for epigenetic factors

D Szukiewicz, S Trojanowski, A Kociszewska… - International journal of …, 2022 - mdpi.com
ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive
age. Despite its incidence, the syndrome … , endocrine, and behavioral factors. Primary clinical …

Polycystic ovary syndrome-epigenetic mechanisms and aberrant microRNA

IR Ilie, CE Georgescu - Advances in clinical chemistry, 2015 - Elsevier
… is highly heterogeneous and it is not yet clear which factorsfactors can modify the clinical
presentation via epigenetic … This review examines the role of epigenetics and miRNA in …

Epigenetic and transcriptional alterations in human adipose tissue of polycystic ovary syndrome

M Kokosar, A Benrick, A Perfilyev, R Fornes… - Scientific reports, 2016 - nature.com
… Genetic and epigenetic factors may predispose women to polycystic ovary syndrome (PCOS)…
and epigenetic changes in adipose tissue that are relevant for development of the disease. …

The role of genetics, epigenetics and lifestyle in polycystic ovary syndrome development: the state of the art

V Bruni, A Capozzi, S Lello - Reproductive Sciences, 2022 - Springer
… of major genetic, epigenetic and environmental factors on the appearance of this … epigenetics
in the appearance of PCOS. Several genes, including those related to adrenal and ovarian

Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome

Z Li, H Huang - Medical hypotheses, 2008 - Elsevier
… Given that the development and inheritance of other adult diseases with fetal origin, which
can be induced by nutritional or environmental factors in utero, usually involves an epigenetic

Characterization of DNA methylation and screening of epigenetic markers in polycystic ovary syndrome

P Cao, W Yang, P Wang, X Li… - Frontiers in cell and …, 2021 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a … ovary. Although the etiology of PCOS is largely
unknown, many studies suggest that aberrant DNA methylation is an important contributing factor

[PDF][PDF] Role of epigenetic modifications in the aberrant CYP19A1 gene expression in polycystic ovary syndrome

E Hosseini, M Shahhoseini, P Afsharian… - Archives of Medical …, 2019 - termedia.pl
… genetic and epigenetic alter… factors in the etiopathogenesis of this syndrome [3, 4]. Although
its exact etiology is poorly understood, some evidence suggests that epigenetic factors are …

[HTML][HTML] Introduction: determinants of polycystic ovary syndrome

R Azziz - Fertility and sterility, 2016 - Elsevier
… (eg, gene variants, epigenetic, and race/ethnicity) factors. Finally a … additional insight into
those factors determining the etiology, … Epigenetics in polycystic ovary syndrome: a pilot study of …