The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
TH Rushmore, MR Morton, CB Pickett - Journal of Biological Chemistry, 1991 - Elsevier
… the ARE represents a cis-acting regulatory element which is responsive to oxidative stress.
… This sequence, which has been named the electrophile responsive element, contains the …
… This sequence, which has been named the electrophile responsive element, contains the …
Antioxidant response element
AK Jaiswal - Biochemical pharmacology, 1994 - Elsevier
… and oxidative stress [15,16]. The ARE sequences are also expected to be present in the
promoters of EH and UDP-GT genes and are the subject of great interest. These observations …
promoters of EH and UDP-GT genes and are the subject of great interest. These observations …
Active defense under oxidative stress. The antioxidant responsive element
VV Lyakhovich, VA Vavilin, NK Zenkov… - Biochemistry …, 2006 - Springer
… of genes regulated by the antioxi dant responsive element (ARE). The latter is important
for cell defense under conditions of oxidative stress and also for detoxification of electrophilic …
for cell defense under conditions of oxidative stress and also for detoxification of electrophilic …
[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress
C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
… In the nucleus, Nrf2 heterodimerizes with small Maf proteins and binds to the antioxidant
response element (ARE), activating the expression of a battery of cytoprotective genes. …
response element (ARE), activating the expression of a battery of cytoprotective genes. …
The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
T Nguyen, P Nioi, CB Pickett - Journal of biological chemistry, 2009 - ASBMB
… oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element …
In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway …
In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway …
[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
… encoding antioxidant proteins, … oxidative stress. This articulated universal mechanism is
regulated through the cis-acting elements in an array of Nrf2 target genes called antioxidant …
regulated through the cis-acting elements in an array of Nrf2 target genes called antioxidant …
Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis
PH Shih, CT Yeh, GC Yen - Journal of agricultural and food …, 2007 - ACS Publications
… to the activation of antioxidant response element (ARE) upstream of … stimulate the antioxidant
system to resist oxidant-induced … in modulating the defense system against oxidative stress. …
system to resist oxidant-induced … in modulating the defense system against oxidative stress. …
Microarray analysis reveals an antioxidant responsive element-driven gene set involved in conferring protection from an oxidative stress-induced apoptosis in IMR-32 …
J Li, JM Lee, JA Johnson - Journal of Biological Chemistry, 2002 - ASBMB
… of the antioxidant responsive element is critical for generating this protective response. Addition
… Many of these genes function to combat oxidative stress and increase the detoxification …
… Many of these genes function to combat oxidative stress and increase the detoxification …
Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element
I Chowdhury, Y Mo, L Gao, A Kazi, AB Fisher… - Free Radical Biology …, 2009 - Elsevier
… and the mechanism for induction of Prdx6 by oxidant stress. We identified a functional
antioxidant-response element (ARE) [23], also called an electrophile-response element [24], in the …
antioxidant-response element (ARE) [23], also called an electrophile-response element [24], in the …
Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
… The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative
stress-inducing agents. Role for Nrf1 in γ-gcs L and gss expression in mouse fibroblasts …
stress-inducing agents. Role for Nrf1 in γ-gcs L and gss expression in mouse fibroblasts …