PAMAM dendrimers in drug delivery: Loading efficacy and polymer morphology

P Chanphai, L Bekale… - Canadian Journal of …, 2017 - cdnsciencepub.com
… Taken together, our data suggest that PAMAM dendrimers are capable of transporting
doxorubicin and tamoxifen in vitro. This demonstrates the importance of PAMAM dendrimers as a …

PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
… The TMScu encapsulation efficacy and the drug loading rates were 77.8 ± 0.69% and 6.2
± 0.06%, respectively. Also, the highest percentage of TMScu release from the TMScu/…

PEGylated PAMAM dendrimers: Enhancing efficacy and mitigating toxicity for effective anticancer drug and gene delivery

D Luong, P Kesharwani, R Deshmukh, MCIM Amin… - Acta biomaterialia, 2016 - Elsevier
… PEGylated PAMAM dendrimers have a higher anticancer drugs loading with the sustained
and controlled drug release property for efficient tumor uptake [21], [22]. PEGylated …

Characterization of folic acid-PAMAM conjugates: drug loading efficacy and dendrimer morphology

P Chanphai, HA Tajmir-Riahi - Journal of Biomolecular Structure …, 2018 - Taylor & Francis
… We report the loading efficacy of folic acid (FA) by polyamidoamine (PAMAM-G3 and
PAMAM-G4) nanoparticles in aqueous solution at physiological pH. Thermodynamic parameters …

Studies on PEGylated and drug-loaded PAMAM dendrimers

G Pan, Y Lemmouchi, EO Akala… - Journal of bioactive and …, 2005 - journals.sagepub.com
… these PEG conjugated PAMAM dendrimers were studied. The percentage coverage of
PAMAM dendrimer surface with PEG had little effect on the encapsulation efficiency but affected …

Intratumor performance and therapeutic efficacy of PAMAM dendrimers carried by clustered nanoparticles

HJ Li, J Liu, YL Luo, SB Chen, R Liu, JZ Du… - Nano Letters, 2019 - ACS Publications
efficacy in an orthotopic pancreatic tumor model. The mechanistic study revealed that G3-PAMAM
weak cell internalization, while G7-PAMAM was much less penetrative because of its …

Dendrimer-based nanocarriers demonstrating a high efficiency for loading and releasing anticancer drugs against cancer cells in vitro and in vivo

NQ Tran, CK Nguyen, TP Nguyen - Advances in Natural …, 2013 - iopscience.iop.org
PAMAM dendrimer G 2.5 were prepared for loading anticancer drugs. For loading cisplatin,
carboxylated dendrimer … Pegylated PAMAM dendrimers (G 3.0) were synthesized below 40 …

PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect

MN Ho, LG Bach, DH Nguyen, CH Nguyen… - …, 2019 - Wiley Online Library
… To explore the oxaliplatin carrying ability of PEGylated dendrimer G4.0, drug loading efficiency
(DLE) was determined, and the oxaliplatin releasing kinetic was investigated. To evaluate …

Poly (amidoamine)(PAMAM) dendrimer mediated delivery of drug and pDNA/siRNA for cancer therapy

J Li, H Liang, J Liu, Z Wang - International journal of pharmaceutics, 2018 - Elsevier
… Moreover, the secondary interactions between the PAMAM dendrimers and the loaded
uptake of siRNA and higher loading efficiency for doxorubicin. In another important study, …

Co-delivery of doxorubicin and TRAIL plasmid by modified PAMAM dendrimer in colon cancer cells, in vitro and in vivo evaluation

E Pishavar, M Ramezani, M Hashemi - Drug Development and …, 2019 - Taylor & Francis
… Drug loading into modified PAMAM In order to increase transfection efficiency and loading
capacity of PAMAM dendrimer as a co-delivery system, 10-bromodecanoic acid, PEG, and …