… Preclinical evaluation is essential for a rational design of … may progress and patients virtually
become unresponsive to … So far, only two studies have demonstrated a chemosensitizer …

… Based on promising preclinical studies, DNA methylation … and biological endpoints for
evaluating patient responses. In … (B) This chemosensitization is hypothesized to be due to the …

… Data obtained from preclinical studies on low dose … for the treatment of patients with advanced
hematological malignancies, … In this minireview, we will summarize preclinical studies on …

… of tumors, and has already demonstrated positive clinical results in patients. In this review, …
modulation has shown controversial results in preclinical studies. For instance, it has been …

… lipophilicity was particularly important for chemosensitization. The lipophilic analogue
benznidazole (N… These doses are similar to those used in our previous chemosensitization studies …

… Thus, it is important to know the plasma elimination half-life (and, if possible, tissue
elimination half-lives) in preclinical studies so that the length of time a patient should protect …

… patients with a wide variety of solid tumors. New effective strategies are still needed to improve
chemosensitization … Preclinical and clinical studies focused on combination therapy using …

… A third hypothesis, which essentially provides a mechanistic explanation for the second
hypothesis, is based on our prior preclinical observations regarding the induction of circulating …

… less conventional in preclinical studies, they are used routinely in clinical drug evaluation. On
… -dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer. …

… reducing the toxicity often seen in patients treated with DTX. … promising treatment strategy
for patients with AIPCa. Finally, we … development of future preclinical and clinical studies on the …