Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

M Weber, I Hellmann, MB Stadler, L Ramos, S Pääbo… - Nature …, 2007 - nature.com
promoter methylation (Fig. 1d). In agreement with the link between promoter DNA methylation
… 3 , we also observed that promoter DNA methylation was higher on the X chromosome …

Targets and dynamics of promoter DNA methylation during early mouse development

J Borgel, S Guibert, Y Li, H Chiba, D Schübeler… - Nature …, 2010 - nature.com
… We conclude that promoter DNA methylation acquired in epiblast can be … at promoters with
moderate CpG richness during somatic development. Figure 3: Promoter DNA methylation at …

Epigenetic biomarkers of promoter DNA methylation in the new era of cancer treatment

K Yamashita, K Hosoda, N Nishizawa, H Katoh… - Cancer …, 2018 - Wiley Online Library
… review the published literatures describing DNA methylation in the promoters of critical
tumor suppressor genes; detection of promoter DNA methylation in various body fluids permits …

Cyclical DNA methylation of a transcriptionally active promoter

R Métivier, R Gallais, C Tiffoche, C Le Péron… - Nature, 2008 - nature.com
… of the pS2 promoter 14 . Significantly, the NuRD complex engages the promoter 2 h after E 2
… We envisioned that DNA methylation may target NuRD to the promoter at this specific time, …

Transient cyclical methylation of promoter DNA

S Kangaspeska, B Stride, R Métivier… - Nature, 2008 - nature.com
… actively transcribed, DNA methylation occurs after the … methylation cycling of the pS2
promoter in cell lines in which pS2 expression is quiescent and the proximal promoter is methylated

DNA methylation landscapes: provocative insights from epigenomics

MM Suzuki, A Bird - Nature reviews genetics, 2008 - nature.com
… that sees DNA methylation primarily … DNA methylation — are currently seen as limited.
However, studies of large numbers of promoters have revealed many at which DNA methylation

DNA methylation

R Singal, GD Ginder - Blood, The Journal of the American …, 1999 - ashpublications.org
… Numerous reports have shown the ability of promoter DNA methylation to inhibit
transcription of a wide variety of genes in in vitro transfection assays, and in some cases, such …

DNA methylation: roles in mammalian development

ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
… Before exploring dynamic regulation within selected cellular systems, we provide a
breakdown of DNA methylation as it acts on promoters, repetitive elements and parent-specific …

DNA methylation and cancer

M Kulis, M Esteller - Advances in genetics, 2010 - Elsevier
… The majority of the promoters affected by loss of DNA methylation belong to tissue-specific
genes. For instance, a family of cancer/testis (CT) antigens, which are restricted to adult …

Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging

MT Bocker, I Hellwig, A Breiling… - Blood, The Journal …, 2011 - ashpublications.org
… SLAMF7 was restricted to the promoter region, whereas the gene body remained methylated,
which is consistent with a specific role of promoter DNA methylation in gene silencing. Our …