Recombinant SARS-CoV-2 genomes circulated at low levels over the first year of the pandemic

D VanInsberghe, AS Neish, AC Lowen… - Virus Evolution, 2021 - academic.oup.com
recombinant SARS-CoV-2 genomes, they represent an extremely small fraction of the
genomes … Although our de novo mutation filtering is likely removing some true recombinant

[HTML][HTML] Recombinant SARS-CoV-2 genomes are currently circulating at low levels

D VanInsberghe, AS Neish, AC Lowen, K Koelle - BioRxiv, 2021 - ncbi.nlm.nih.gov
… of putative recombinants, we next sought to use these sequences to ask whether recombination
hotspots in the SARS-CoV-2 genome may be apparent. The limited genome diversity …

Generation and transmission of interlineage recombinants in the SARS-CoV-2 pandemic

B Jackson, MF Boni, MJ Bull, A Colleran… - Cell, 2021 - cell.com
… To identify putative SARS-CoV-2 recombinant viruses, we carried out an analysis of all
complete UK SARS-CoV-2 genomes that had been assigned to lineage B.1.1.7 and that showed …

A comparative recombination analysis of human coronaviruses and implications for the SARS-CoV-2 pandemic

S Pollett, MA Conte, M Sanborn, RG Jarman… - Scientific Reports, 2021 - nature.com
… Specifically, we aimed to identify the frequency and genomic location of recombination
Among SARS-CoV-2 genomes, we detected a total of 8 recombination events detected by at least …

On the origin and evolution of SARS-CoV-2

D Singh, SV Yi - Experimental & molecular medicine, 2021 - nature.com
… mutational variability into this genome, increasing opportunities for future recombination. …
on their genomic position in the SARS-CoV-2 genome model (top panel). b Two scenarios …

Genome‐based comparison between the recombinant SARSCoV2 XBB and its parental lineages

F Scarpa, D Sanna, I Azzena, M Casu… - Journal of Medical …, 2023 - Wiley Online Library
… In conclusion, the genome-based survey of the SARS-CoV-2 recombinat XBB and on its first
sublineage XBB.1 suggest that, although this new lineage presents several spike mutations …

Generation and Characterization of recombinant SARS-CoV-2 expressing reporter genes

K Chiem, D Morales Vasquez, JG Park, RN Platt… - Journal of …, 2021 - Am Soc Microbiol
SARS-CoV-2 infection and associated COVID-19. … recombinant SARS-CoV-2 (rSARS-CoV-2)
constructs expressing fluorescent (Venus and mCherry) or luciferase (Nluc) reporter genes

Pandemic-scale phylogenomics reveals the SARS-CoV-2 recombination landscape

Y Turakhia, B Thornlow, A Hinrichs, J McBroome… - Nature, 2022 - nature.com
… breakpoint positions 11 , our data indicates that other biases shape the distribution of
recombination events across the SARS-CoV-2 genome. These could include a neutral mechanistic …

Second-generation SARS-CoV-2 recombinants: Lessons from other viruses

D Focosi, F Maggi - Viruses, 2023 - mdpi.com
… possible in any RNA virus, the rates of recombination vary markedly among … genomes,
exhibit such low rates of recombination that they are effectively clonal. Although recombination is …

Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America

B Gutierrez, HGC Sánchez, D da Silva Candido… - Cell Host & Microbe, 2022 - cell.com
… Our understanding of the effects of genomic recombination on SARS-CoV-2 fitness and
transmission dynamics is still limited, but genetic exchange has been previously associated with …