The domestic laying hen is the only non-human animal that spontaneously develops ovarian
cancer with a high prevalence. Hens ovulate prolifically, and this has made the hen …

The high mortality rate due to ovarian cancer (OVCA) is attributed to the lack of an effective
early detection method. Because of the nonspecificity of symptoms at early stage, most of the …

The laying hen (Gallus domesticus) is a robust animal model for epithelial ovarian cancer.
The use of animal models is critical in identifying early disease markers and developing and …

The lack of preclinical models of spontaneous ovarian cancer (OVCA), a fatal gynecological
malignancy, is a significant barrier to generating information on early changes indicative of …

Objective: The main goal of this study was to compare the incidence of ovarian cancer (OC)
in 2 genetically different lines of hens-one that generally fails to lay eggs (the mutant" …

Ovarian cancer has a high mortality rate due, in part, to the lack of early detection and
incomplete understanding of the origin of the disease. The hen is the only spontaneous …

Objective. A significant obstacle confronting the evaluation of potential chemopreventive
compounds in ovarian carcinoma is the absence of an animal model of spontaneous …

The domestic laying chicken has been intensely selected to be a persistent ovulator. That is,
the tendency for broodiness has been nearly eliminated and, given the appropriate lighting …

We examined alterations in the p53 tumor suppressor gene and the ras and HER-2/neu
oncogenes in chicken ovarian cancers to determine if these tumors have genetic alterations …

OBJECTIVE: We hypothesized that ovarian tumors without oviductal involvement would not
express the oviductal protein ovalbumin, the major protein found in the magnum of the hen's …