DNA methylation (DNAm) is important in brain development and is potentially important in
schizophrenia. We characterized DNAm in prefrontal cortex from 335 non-psychiatric …

Background Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to
result from disturbances in early brain development. There is mounting evidence to support …

DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …

Background The importance of cell type-specific epigenetic variation of non-coding regions
in neuropsychiatric disorders is increasingly appreciated, yet data from disease brains are …

Genetic association studies provide evidence for a substantial polygenic component to
schizophrenia, although the neurobiological mechanisms underlying the disorder remain …

We characterized DNA methylation quantitative trait loci (mQTLs) in a large collection (n=
166) of human fetal brain samples spanning 56–166 d post-conception, identifying> 16,000 …

Background: Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of
0.5–1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating …

Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …

Extensive changes in DNA methylation have been observed in schizophrenia (SC) and
bipolar disorder (BP), and may contribute to the pathogenesis of these disorders. Here, we …

Importance DNA methylation may play an important role in schizophrenia (SZ), either
directly as a mechanism of pathogenesis or as a biomarker of risk. Objective To scan …