Chromatin domain alterations linked to 3D genome organization in a large cohort of schizophrenia and bipolar disorder brains
Chromosomal organization, scaling from the 147-base pair (bp) nucleosome to megabase-
ranging domains encompassing multiple transcriptional units, including heritability loci for …
ranging domains encompassing multiple transcriptional units, including heritability loci for …
Epigenetic mechanisms expressed in basal ganglia GABAergic neurons differentiate schizophrenia from bipolar disorder
In the cerebral prefrontal cortex (PFC), DNA-methyltransferase 1 (DNMT1), the enzyme that
catalyzes the methylation of cytosine at carbon atoms in position 5 in CpG dinucleotides, is …
catalyzes the methylation of cytosine at carbon atoms in position 5 in CpG dinucleotides, is …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Methylomic trajectories across human fetal brain development
Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …
development. The importance of DNA methylation in fetal brain development is highlighted …
DNA methylation in peripheral tissue of schizophrenia and bipolar disorder: a systematic review
Background Increasing evidence suggests the involvement of epigenetic processes in the
development of schizophrenia and bipolar disorder, and recent reviews have focused on …
development of schizophrenia and bipolar disorder, and recent reviews have focused on …
Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset
Even though schizophrenia has a strong hereditary component, departures from simple
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …
genetic transmission are prominent. DNA methylation has emerged as an epigenetic …
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …
genotype data in order to test associations between disease and gene expression. These …
Epigenetic mechanisms in schizophrenia
S Akbarian - Dialogues in clinical neuroscience, 2014 - Taylor & Francis
Schizophrenia is a major psychiatric disorder that lacks a unifying neuropathology, while
currently available pharmacological treatments provide only limited benefits to many …
currently available pharmacological treatments provide only limited benefits to many …
Sex-differential DNA methylation and associated regulation networks in human brain implicated in the sex-biased risks of psychiatric disorders
Many psychiatric disorders are characterized by a strong sex difference, but the mechanisms
behind sex-bias are not fully understood. DNA methylation plays important roles in …
behind sex-bias are not fully understood. DNA methylation plays important roles in …
Puzzling over schizophrenia: schizophrenia as a pathway disease
PF Sullivan - Nature medicine, 2012 - nature.com
Effective treatment for schizophrenia is still an unmet clinical need. Alleviating problems
associated with cognitive impairment and finding the root of the disease remain priorities for …
associated with cognitive impairment and finding the root of the disease remain priorities for …