[HTML][HTML] Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
Background Alternative splicing is a key regulatory mechanism in eukaryotic cells and
increases the effective number of functionally distinct gene products. Using bulk RNA …
increases the effective number of functionally distinct gene products. Using bulk RNA …
[HTML][HTML] Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries
Most human genes are alternatively spliced, allowing for a large expansion of the proteome.
The multitude of regulatory inputs to splicing limits the potential to infer general principles …
The multitude of regulatory inputs to splicing limits the potential to infer general principles …
Genetic variation of pre‐mRNA alternative splicing in human populations
The precise splicing outcome of a transcribed gene is controlled by complex interactions
between cis regulatory splicing signals and trans‐acting regulators. In higher eukaryotes …
between cis regulatory splicing signals and trans‐acting regulators. In higher eukaryotes …
[HTML][HTML] Promoter-like epigenetic signatures in exons displaying cell type-specific splicing
Background Pre-mRNA splicing occurs mainly co-transcriptionally, and both nucleosome
density and histone modifications have been proposed to play a role in splice site …
density and histone modifications have been proposed to play a role in splice site …
[HTML][HTML] Thousands of exon skipping events differentiate among splicing patterns in sixteen human tissues
Alternative splicing is widely recognized for its roles in regulating genes and creating gene
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …
diversity. However, despite many efforts, the repertoire of gene splicing variation is still …
[HTML][HTML] Computational identification of tissue-specific splicing regulatory elements in human genes from RNA-Seq data
Alternative splicing is a vital process for regulating gene expression and promoting
proteomic diversity. It plays a key role in tissue-specific expressed genes. This specificity is …
proteomic diversity. It plays a key role in tissue-specific expressed genes. This specificity is …
[HTML][HTML] BRIE2: computational identification of splicing phenotypes from single-cell transcriptomic experiments
Y Huang, G Sanguinetti - Genome biology, 2021 - Springer
RNA splicing is an important driver of heterogeneity in single cells through the expression of
alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic …
alternative transcripts and as a determinant of transcriptional kinetics. However, the intrinsic …
Diversification of stem cell molecular repertoire by alternative splicing
M Pritsker, TT Doniger, LC Kramer… - Proceedings of the …, 2005 - National Acad Sciences
Complete information regarding transcriptional and posttranscriptional gene regulation in
stem cells is necessary to understand the regulation of self-renewal and differentiation …
stem cells is necessary to understand the regulation of self-renewal and differentiation …
Robust and annotation-free analysis of alternative splicing across diverse cell types in mice
Although alternative splicing is a fundamental and pervasive aspect of gene expression in
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …
[HTML][HTML] A survey of software for genome-wide discovery of differential splicing in RNA-Seq data
JE Hooper - Human genomics, 2014 - Springer
Alternative splicing is a major contributor to cellular diversity. Therefore the identification and
quantification of differentially spliced transcripts in genome-wide transcript analysis is an …
quantification of differentially spliced transcripts in genome-wide transcript analysis is an …