The serotonin (5-HT) transporter from human striatum was solubilized by digitonin and
purified by affinity chromatography. The native protein-detergent complex had a molecular …

Abstract The serotonin (5-HT) transporter from calf striatum cerebral membranes was
solubilized with digitonin and characterized by gel exclusion chromatography.[3 H] …

1. Regional distribution of the serotonin transport complex was studied in 12 different brain
areas from human brains. The serotonin uptake complex was measured with 3 H …

The 5-hydroxytryptamine transporter complex from rat cerebral cortical membranes was
solubilized with digitonin. The affinity of the solubilized transporter complex for [3 H] …

Previous studies have demonstrated that [3H] paroxetine and [3H] cyanoimipramine ([3H]
CN-IMI) are highly selective ligands for the serotonin (5-HT) transporter. Using membrane …

The binding of [3H] paroxetine and [3H] citalopram to the human brain serotonin (5-HT)
uptake site has been characterized and compared. Our results reveal that the binding …

Citalopram binds with high affinity to a specific binding site located on the serotonin (5-HT)
transporter in 5-HT neurons. The binding affinity of [3 H] citalopram was found to increase …

The effects of 5‐hydroxytryptamine (5‐HT) and 5‐HT uptake inhibitors on the dissociation of
[3H] paroxetine from rat brain membrane binding sites have been investigated. The …

The serotonin transporter (5-HTT) plays a critical role in the termination of serotonin
neurotransmission and represents the prime target for selective serotonin reuptake inhibitors …

Tricyclic antidepressants are believed to exert their therapeutic action by blocking the
reuptake of catecholamines and serotonin (5-HT) from synaptic terminals (Fuller and Wong …