Introduction Oral administration of poorly water-soluble drugs (PWSDs) is generally related
to low bioavailability, leading to high drug doses, multiple side effects, and low patient …

The low water solubility of pharmacoactive molecules limits their pharmacological potential,
but the solubility parameter cannot compromise, and so different approaches are employed …

Introduction: In the past two decades, there has been a spiraling increase in the complexity
and specificity of drug–receptor targets. It is possible to design drugs for these diverse …

Poorly water soluble compounds have solubility and dissolution related bioavailability
problems. The dissolution rate is directly proportional to solubility of drugs. Drugs with low …

A wide variety of new medication disclosures launched by specific benefits of the general
public are laced with poor aqueous solubility problems that often obstruct their bioavailability …

Poorly water-soluble drugs continue to be a problematic, yet important class of
pharmaceutical compounds for treatment of a wide range of diseases. Their prevalence in …

An ideal drug delivery system should be able to deliver an adequate amount of drug,
preferably for an extended period of time for its optimum therapeutic activity. Most drugs are …

High-throughput screening (HTS) methodologies for lead identification in drug discovery
were developed in the 1980s to enable the utilization of advances in genomics and …

Water solubility is a key parameter in drug formulation since it highly influences drug
pharmacokinetics and pharmacodynamics. In the past decades, the challenge with poorly …

Delivering drugs in a water-insoluble formulation is a critical matter in therapeutic drug
development. However, because a drug molecule has to be water soluble to be readily …