Recessively inherited phenotypes are frequent in the Palestinian population, as the result of
a historical tradition of marriages within extended kindreds, particularly in isolated villages …

The genetic characterization of a common phenotype for an entire population reveals both
the causes of that phenotype for that place and the power of family-based, population-wide …

In some Palestinian communities, the prevalence of inherited prelingual deafness is among
the highest in the world. As an initial step towards understanding the genetic causes of …

Background Hearing loss is a clinically and genetically heterogeneous disorder. Mutations
in the DFNB1 locus have been reported to be the most common cause of autosomal …

In communities with high rates of consanguinity and consequently high prevalence of
recessive phenotypes, homozygosity mapping with SNP arrays is an effective approach for …

Aim: To investigate the causative genetic mutations in 12 Pakistani families with
nonsyndromic or syndromic hearing loss. Methods: Mutations in the most common causative …

Approximately 14.5 million Pakistani individuals have a hearing loss and half of these cases
may be due to genetic causes. Though significant progress has been made in uncovering …

The current molecular genetic diagnostic rates for hereditary hearing loss (HL) vary
considerably according to the population background. Pakistan and other countries with …

Although variant alleles of hundreds of genes are associated with sensorineural deafness in
children, the genes and alleles involved remain largely unknown in the Sub-Saharan …

Nonsyndromic hearing loss is an extremely heterogeneous disorder. Thus, clinical
diagnostics is challenging, in particular due to differences in the etiology of hearing loss …