HYPOTHERMIC PERFUSION OF THE KIDNEY: FROM RESEARCH TO CLINICAL PRACTICE

G Radi, G Fallani, G Germinario… - European Journal …, 2023 - eujtransplantation.com
Kidney transplantation is the treatment of choice for patients with end stage renal disease
(ESRD). Donor availability is lower than demand, therefore suboptimal grafts retrieved from …

Hypothermic Machine Perfusion of Kidney Transplant: A Mini-Review

V Tatsis, E Dounousi, M Mitsis - Transplantation Proceedings, 2021 - Elsevier
Most kidney grafts are marginal and from deceased donors, which yield worse clinical
outcomes. Hypothermic machine perfusion has created a paradigm shift in kidney …

Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Normothermic ex vivo perfusion of deceased donor kidneys and its clinical potential in kidney transplantation outcomes

M Unes, K Kurashima, Y Caliskan… - … Journal of Artificial …, 2023 - journals.sagepub.com
In recent years, normothermic machine perfusion (NMP) has emerged in conversation
surrounding organ preservation and transplantation techniques with the goal of improving …

Oxygenated hypothermic machine perfusion of kidneys donated after circulatory death: an international randomised controlled trial

I Jochmans, HS Hofker, L Davies… - 26th BTS Annual …, 2019 - dial.uclouvain.be
METHODS: An international, double-blinded, randomised, paired trial investigated the effect
of oxygenated (HMPO) vs non-oxygenated hypothermic machine perfusion (HMP) on 1y …

Oxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial

I Jochmans, A Brat, L Davies, HS Hofker… - The Lancet, 2020 - thelancet.com
Background Deceased donor kidneys are preserved in cold hypoxic conditions. Providing
oxygen during preservation might improve post-transplant outcomes, particularly for kidneys …

Short, cool, and well oxygenated–HOPE for kidney transplantation in a rodent model

P Kron, A Schlegel, O de Rougemont… - Annals of …, 2016 - journals.lww.com
Objectives: The aim of this study was to investigate novel and easily applicable preservation
perfusion techniques in kidney grafts obtained from donors after circulatory death (DCD) …

Early experience with hypothermic machine perfusion of living donor kidneys–a retrospective study

MAJ Moser, N Ginther, Y Luo, G Beck… - Transplant …, 2017 - Wiley Online Library
Although hypothermic machine perfusion (HMP) has been shown to be beneficial to
deceased donor kidneys, the effect of HMP on living donor kidneys (LDK) is unknown. LDK …

Hypothermic machine perfusion as a national standard preservation method for deceased donor kidneys

A Brat, KM de Vries, EWE van Heurn… - …, 2022 - journals.lww.com
Background. Recently, continuous nonoxygenated hypothermic machine perfusion (HMP)
has been implemented as standard preservation method for deceased donor kidneys in the …

Kidney perfusion: some like it hot others prefer to keep it cool

I Jochmans, ML Nicholson… - Current Opinion in Organ …, 2017 - journals.lww.com
A great deal of research is still needed to optimize and logistically place hypothermic and
normothermic perfusion technologies. In the future, we may progress toward organ-tailored …