BACKGROUND: The involvement of the l-arginine/nitric oxide (NO)/cyclic guanosine
monophosphate (cGMP) pathway in antinociception has been implicated as a molecular …

The l-arginine/nitric oxide/cyclic GMP pathway has been proposed as the mechanism of
action for peripheral antinociception concerning several groups of drugs, including opioids …

In view of the scarce information about the analgesic mechanism of κ-opioid receptor
agonists, the objective of the present study was to determine whether nitric oxide (NO) is …

We investigated the contribution of NO-cyclic GMP (cGMP) pathway to the antinociceptive
effects of ketamine in mice by using the nitric oxide synthase inhibitor, nitrog-L-arginine …

Despite the classical peripheral pronociceptive effect of noradrenaline (NA), recently studies
showed the involvement of NA in antinociceptive effect under immune system interaction. In …

The involvement of the nitric oxide (NO)/cyclic GMP pathway in the molecular mechanisms
of antinociceptive drugs like morphine has been previously shown by our group …

Studies have demonstrated that the L-arginine/NO/cGMP pathway and the potassium and
calcium channels are involved in the mechanisms underlying opioid receptor activation. As …

Opioid receptor agonists induce noradrenaline release in the supraspinal, spinal, and
peripheral sites. Endogenous noradrenaline release can induce an antinociceptive effect by …

Nitricoxide (NO) has been reported to enhance the analgesic effect of the peripherally
administered [micro sign]-opioid receptor agonists, but the role of NO on the analgesic effect …

Abstract Angiotensin-(1–7) is a bioactive component of the renin–angiotensin system that is
formed endogenously and induces nitric oxide release in several tissues. The l …