The role of the supraspinal nitric oxide (NO)/cyclic GMP system in the development of acute
morphine antinociceptive tolerance was investigated by use of the mouse 55° C warm-water …

Background. Ketamine has been found to exert antinociceptive effects in animals and to be
analgesic at subanaesthetic doses in humans. This study was designed to investigate the …

Background Recent studies have revealed that N2O exerts its antinociceptive effect by
inducing opioid peptide release in the brain stem, thereby activating the descending …

Recent studies suggested that the L-arginine/nitric oxide (NO)/cyclic GMP pathway is
involved in the modulation of pain perception. The present experiments were undertaken to …

Objective (s): Growing evidence demonstrates that L-arginine/NO/cGMP/K ATP channel
pathway has a modulatory role in pain perception. Previous studies have shown that …

While much evidence implicates substance P (SP), an endogenous neurokinin (NK), as a
primary sensory transmitter of acute pain in mammalian spinal cord, its role in continuous …

This study assessed the effect of the agonist 15d-PGJ2 administered into the rat
temporomandibular joint (TMJ) on nociceptive behavioral and the anti-inflammatory …

Peripheral inflammation enhances the antinociceptive effects of opioid receptor agonists
through the activation of peripheral opioid receptors whose expression also increases …

We examined the effects of calcium modulators on mu and delta opioid receptor agonist-
induced antinociception in both diabetic and nondiabetic mice. In nondiabetic mice …

Background The amygdala has an important role in pain and pain modulation. We showed
previously in animal studies that α2‐adrenoreceptor activation in the central nucleus of the …