Calcitonin (CT)‐secreting cells (C‐cells) are remarkably sensitive to changes in the
extracellular Ca2+ concentration. In order to detect the mechanism by which C‐cells monitor …

The spontaneous electrical activity of calcitonin-secreting cells (C-cells) appears to play an
important role in the coupling of fluctuations in the extracellular Ca 2+ to changes in the …

1. Calcitonin secretion is regulated by the external Ca2+ concentration ([Ca2+] o) via a rise
in intracellular Ca2+ concentration ([Ca2+] i). The mechanism which couples an increase in …

The whole cell version of the patch-clamp technique was used to identify and characterize
voltage-gated Ca2+, Na+, and K+ currents in the calcitonin-secreting human thyroid TT cell …

1, 4-Dihydropyridine-sensitive voltage-dependent Ca2+ channels play a crucial role in the
extracellular Ca (2+)-sensing of calcitonin-secreting parafollicular cells of the thyroid (C …

An essential function of C-cells is to monitor extracellular Ca2+ concentration ([Ca2+] e) and
to respond to changes in [Ca2+] e by regulating hormone secretion. Using the calcitonin …

Intracellular calcium [Ca2+] i acts as an important intracellular messenger system for
secretion and synthesis, cell growth and differentiation. In order to demonstrate definitively …

The whole cell version of the patch-clamp technique was used to characterize voltage-gated
Ca2+ channels in the calcitonin-secreting rat thyroid C-cell line 6-23 (clone 6). Three types …

Few endocrine tissues can detect changes in the extracellular Ca2+ concentration within the
physiological range and modify their hormone secretion accordingly. A rat cell line of C-cell …

Primary cultures of human medullary thyroid carcinoma tissue were prepared from lymph
node metastases in two patients. The parenchymal, cultured cells displayed positive …