Neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to T and B cells for induction of anti-tumor immunity by allowing generation …

K Sarkar, S Goswami, S Roy, A Mallick… - International …, 2010 - Elsevier
Vaccination with neem leaf glycoprotein matured carcinoembryonic antigen (CEA) pulsed
dendritic cells (DCs) enhances antigen-specific humoral and cellular immunity against CEA …

Neem leaf glycoprotein matures myeloid derived dendritic cells and optimizes anti-tumor T cell functions

S Goswami, A Bose, K Sarkar, S Roy, T Chakraborty… - Vaccine, 2010 - Elsevier
In an objective to find out an effective, nontoxic dendritic cell (DC) maturating agent for
human use, CD14+ monocytes were differentiated with GMCSF/IL-4 and matured with neem …

Neem leaf glycoprotein helps to generate carcinoembryonic antigen specific anti-tumor immune responses utilizing macrophage-mediated antigen presentation

K Sarkar, A Bose, K Chakraborty, E Haque, D Ghosh… - Vaccine, 2008 - Elsevier
In an objective to generate effective carcinoembryonic antigen (CEA) specific anti-tumor
immune response in Swiss mice, CEA was presented using macrophages with adjuvant …

Neem leaf glycoprotein promotes dual generation of central and effector memory CD8+ T cells against sarcoma antigen vaccine to induce protective anti-tumor …

S Ghosh, M Sarkar, T Ghosh, I Guha, A Bhuniya… - Molecular …, 2016 - Elsevier
We have previously shown that Neem Leaf Glycoprotein (NLGP) mediates sustained tumor
protection by activating host immune response. Now we report that adjuvant help from NLGP …

[HTML][HTML] Neem Leaf Glycoprotein Activates CD8+ T Cells to Promote Therapeutic Anti-Tumor Immunity Inhibiting the Growth of Mouse Sarcoma

A Mallick, S Barik, KK Goswami, S Banerjee, S Ghosh… - PLoS …, 2013 - journals.plos.org
In spite of sufficient data on Neem Leaf Glycoprotein (NLGP) as a prophylactic vaccine, little
knowledge currently exists to support the use of NLGP as a therapeutic vaccine. Treatment …

Neem leaf glycoprotein partially rectifies suppressed dendritic cell functions and associated T cell efficacy in patients with stage IIIB cervical cancer

S Roy, S Goswami, A Bose, K Chakraborty… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
Myeloid-derived dendritic cells (DCs) generated from monocytes obtained from stage IIIB
cervical cancer (CaCx IIIB) patients show dysfunctional maturation; thus, antitumor T cell …

A monoclonal antibody against neem leaf glycoprotein recognizes carcinoembryonic antigen (CEA) and restricts CEA expressing tumor growth

A Das, S Barik, S Banerjee, A Bose… - Journal of …, 2014 - journals.lww.com
Carcinoembryonic antigen (CEA) is one of the promising tumor antigens mainly associated
with carcinoma of the colon, lung, breast, etc. and received wide attention for cancer …

[HTML][HTML] Neem leaf glycoprotein optimizes effector and regulatory functions within tumor microenvironment to intervene therapeutically the growth of B16 melanoma in …

S Barik, S Banerjee, M Sarkar, A Bhuniya, S Roy… - Trials in …, 2015 - Elsevier
Therapy with neem leaf glycoprotein (NLGP) inhibits murine B16-melanoma in vivo and
improves survivability. Studies on tumor-microenvironment (TME) from NLGP treated mice …

Induction of type 1 cytokines during neem leaf glycoprotein assisted carcinoembryonic antigen vaccination is associated with nitric oxide production

K Sarkar, A Bose, E Haque, K Chakraborty… - International …, 2009 - Elsevier
Involvement of the nitric oxide (NO) release in CEAMϕNLGP (carcinoembryonic antigen
pulsed macrophages with neem leaf glycoprotein) vaccination and its relationship with …

Neem leaf glycoprotein induces perforin-mediated tumor cell killing by T and NK cells through differential regulation of IFNγ signaling

A Bose, K Chakraborty, K Sarkar… - Journal of …, 2009 - journals.lww.com
We have demonstrated augmentation of the CD3− CD56+ natural killer (NK) and CD8+
CD56− T-cell–mediated tumor cell cytotoxicity by neem leaf glycoprotein (NLGP). These NK …