International cancer registries make real-world genomic and clinical data available, but their
joint analysis remains a challenge. AACR Project GENIE, an international cancer registry …

Next-generation sequencing (NGS), also known as massively parallel sequencing, is rapidly
being incorporated into oncology practice. Interpretation of genomic reports and selecting …

Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

The clinical relevance of comprehensive molecular analysis in rare cancers is not
established. We analyzed the molecular profiles and clinical outcomes of 1,310 patients …

With the increasing use of genomic profiling for diagnosis and therapy guidance in many
tumor types, precision oncology is rapidly reshaping cancer care. However, the current …

The majority of US adult cancer patients today are diagnosed and treated outside the
context of any clinical trial (that is, in the real world). Although these patients are not part of a …

Precision oncology involves identifying drugs that will effectively treat a tumor and then
prescribing an optimal clinical treatment regimen. However, most first-line chemotherapy …

Precision medicine continues to be the benchmark to which we strive in cancer research.
Seeking out actionable aberrations that can be selectively targeted by drug compounds …

BACKGROUND. Comprehensive genomic profiling of a patient's cancer can be used to
diagnose, monitor, and recommend treatment. Clinical implementation of tumor profiling in …

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ
between individual patients and even among individual tumor regions. In recent years, large …