Background DNA methylation is an important epigenetic mechanism involved in gene
regulation, with alterations in DNA methylation in the nuclear genome being linked to …

Background There is growing interest in the role of DNA methylation in regulating the
transcription of mitochondrial genes, particularly in brain disorders characterized by …

Quantification of DNA methylation can be achieved using bisulfite sequencing, which takes
advantage of the property of sodium bisulfite to convert unmethylated cytosine into uracil, in …

The field of mitochondrial epigenetics has received increased attention in recent years and
changes in mitochondrial DNA (mtDNA) methylation has been implicated in a number of …

Mitochondrial dysfunction plays critical roles in cancer development and related therapeutic
response; however, exact molecular mechanisms remain unclear. Recently, alongside the …

Despite decades of research, mitochondrial epigenetics remains a controversial notion.
Recent findings, however, indicate that dysfunctional mitochondrial DNA (mtDNA) …

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

DNA methylation and histone modifications across the nuclear genome have been
extensively analyzed, but the epigenetic modifications associated with the mitochondrial …

Recent expansion of our knowledge on epigenetic changes strongly suggests that not only
nuclear DNA (nDNA), but also mitochondrial DNA (mtDNA) may be subjected to epigenetic …

Methylation of nuclear genes encoding mitochondrial proteins participates in the regulation
of mitochondria function. The existence of cytosine methylation in the mitochondrial genome …