Monitoring of hepatic function during amiodarone therapy

PT Pollak, YD You - American Journal of Cardiology, 2003 - ajconline.org
After many years of benign use in Europe, amiodarone developed a reputation for frequent
adverse effects after its introduction to North America at higher doses. 1, 2 Two decades …

Use of population modeling to define rational monitoring of amiodarone hepatic effects

PT Pollak, SL Shafer - Clinical Pharmacology & Therapeutics, 2004 - Wiley Online Library
Background Amiodarone causes hepatotoxicity in experimental models, but in humans, the
relationships between drug administration, serum concentrations, markers of liver function …

[引用][C] Amiodarone‐associated cirrhosis with hepatic and lymph node granulomas

RF Harrison, E Elias - Histopathology, 1993 - Wiley Online Library
Discussion The radiological, macroscopic and histological features of this case are typical of
a bizarre parosteal osteochondromatous proliferation. This tumour typically occurs on the …

[HTML][HTML] Amiodarone-induced multi-systemic toxicity involving the liver, lungs, thyroid, and eyes: a case report

HS You, JH Yoon, SB Cho, YD Choi, YH Kim… - Frontiers in …, 2022 - frontiersin.org
Objectives Amiodarone is widely used to treat arrhythmia. However, amiodarone is known
for its severe toxicity to the liver, lungs, and thyroid. Amiodarone causes liver damage …

Amiodarone-induced hepatic and pulmonary toxicity

LT Keng, MT Liao - Postgraduate Medical Journal, 2018 - academic.oup.com
An 88-year-old woman presented with a 5-day history of nausea, vomiting and abdominal
pain at the emergency department. Her medical history included sick sinus syndrome and …

Rapidly fatal acute amiodarone hepatitis occurring in the context of multiple organ failure

RJ MacFadyen, TJ Palmer… - International …, 2003 - internationaljournalofcardiology.com
Amiodarone remains the agent of choice for the 80 mmHg and clinical and radiological
evidence of management of atrial fibrillation in unstable patients fluid overload. He was …

Acute liver injury after intravenous amiodarone: a case report.

A Verhovez, F Elia, A Riva, G Ferrari… - The American journal of …, 2010 - europepmc.org
Acute hepatotoxicity is a rare but potentially fatal complication of amiodarone use. Although
oral long-term use of the drug is frequently complicated by an asymptomatic rise in serum …

Amiodarone concentrations in plasma and fat tissue during chronic treatment and related toxicity

C Lafuente‐Lafuente, JC Alvarez… - British journal of …, 2009 - Wiley Online Library
WHAT IT IS ALREADY KNOW ABOUT THIS SUBJECT• Amiodarone is a highly effective
antiarrhythmic drug, but is limited in practice by its adverse effects, which are frequent on …

Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone

JE Tisdale, SL Follin, A Ordelova… - The Journal of Clinical …, 1995 - Wiley Online Library
Noncardiovascular adverse effects associated with amiodarone result in substantial
morbidity. Adverse effects involving the skin, liver, thyroid, and lungs have been reported in …

Multisystem side effects of amiodarone

SU Rehman, N Siddiqui, NS Khan, R Sobia… - The American journal …, 2015 - amjmedsci.com
A60-year-old man with medical history of atrial fibrillation on amiodarone 400 mg/d for 8
years was admitted for increased shortness of breath. On his general physical examination …