The development of melanocytes is regulated by the tyrosine kinase receptor c-KIT and the
basic-helix-loop-helix-leucine zipper transcription factor Mitf. These essential melanocyte …

During melanocyte development, the cytokine Steel factor activates its receptor c-Kit,
initiating a signal transduction cascade, which is vital for lineage determination via unknown …

Many studies have highlighted the critical role of c-Kit in normal melanocyte development
but its role in melanoma development remains unclear. Although c-Kit expression is often …

Microphthalmia (Mi) is a bHLHZip transcription factor that is essential for melanocyte
development and postnatal function. It is thought to regulate both differentiated features of …

purpose. This study was conducted to investigate the expression and functional impact of
the proto-oncogene c-kit in uveal melanoma. methods. Based on immunohistochemical …

The B-Raf V599E-mediated constitutive activation of ERK1/2 is involved in establishing the
transformed phenotype of some uveal melanoma cells (Calipel, A., Lefevre, G., Pouponnot …

Microphthalmia transcription factor (MITF) and STAT3 are two transcription factors that play a
major role in the regulation of growth and function in mast cells and melanocytes. In the …

Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and
migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some …

TheKITgene encodes c-kit, a transmembrane receptor that has tyrosine kinase activity and
plays a role in haematopoiesis, gametogenesis and melanogenesis. The c-kit protein is …

Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte
development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in …