“The precise knowledge of the structure of biological macromolecules forms the basis of
understanding of their function and their mechanism of action”, H. Michel [l]. The bottleneck …

Crystals built of protein, virus, DNA and other big biological molecules are needed to study
atomic structure and functions of these molecules by X-ray diffraction. Crystals of several …

Strategies for growing protein crystals have for many years been essentially empirical, the
protein, once purified to a certain homogeneity, being mixed with a selection of …

Publisher Summary Crystallization of a macromolecule in a form suitable for X-ray diffraction
studies involves the optimization of many solution parameters. This chapter explains the way …

The nucleation of protein crystals is reconsidered taking into account the specificity of the
protein molecules. In contrast to the homogeneous surface properties of small molecules …

Until recently, crystallization of macromolecules was rather an empirical process.
Developments in biotechnology have emphasized the need for a more rational approach …

The concentration changes in a protein solution that are caused by the nucleation and
crystal growth have been measured under various well-defined conditions. The results have …

MECHANISMS OF NUCLEATION AND GROWTH OF PROTEIN CRYSTALS G. FEHER A
systematic investigation of the crystallization j-mers equili Page 1 Journal ofCrystal Growth 76 …

After an historical introduction and justification of the importance of proteins (as well as other
macromolecules or macromolecular assemblies of biological origin) in modern biology but …

The growth of large and well ordered protein crystals remains the major obstacle in protein
structure determination by means of X-ray crystallography. One of the reasons is that the …