After nerve injury, Schwann cells proliferate and revert to a phenotype that supports nerve
regeneration. This phenotype-changing process can be viewed as Schwann cell …

Abstract Adenosine 5′-triphosphate (ATP) is implicated in intercellular communication as a
neurotransmitter in the peripheral nervous system. In addition, ATP is known as lysosomal …

Studies have shown that lysosomal activation increases in Schwann cells after nerve injury.
Lysosomal activation is thought to promote the engulfment of myelin debris or fragments of …

The ubiquitin‐proteasome system (UPS), lysosomes, and autophagy are essential protein
degradation systems for the regulation of a variety of cellular physiological events including …

As lysosomal hydrolysis has long been suggested to be responsible for myelin clearance
after peripheral nerve injury, in this study, we investigated the possible role of …

Injury to the peripheral axons of sensory neurons strongly enhances the regeneration of
their central axons in the spinal cord. It remains unclear on what molecules that initiate such …

Schwann cells (SCs) de-differentiate in Wallerian degeneration (WD) following nerve injury
and, by doing so, can actively promote nerve repair and functional recovery. An innate …

Background Many changes in gene expression occur in distal stumps of injured nerves but
the transcriptional control of these events is poorly understood. We have examined the …

Injured nerve terminals of neuromuscular junctions (NMJs) can regenerate. This remarkable
and complex response is governed by molecular signals that are exchanged among the …

Peripheral nerve injury is followed by a wave of Schwann cell proliferation in the distal nerve
stumps. To resolve the role of Schwann cell proliferation during functional recovery of the …