Background Sleep deprivation (SD) is an antidepressant intervention with multiple
administration formats that has been investigated primarily with uncontrolled clinical trials …

Objective To systematically review evidence on the efficacy and safety of sleep deprivation
(SD) as a treatment option for patients with unipolar or bipolar depression. Methods A …

Background Bipolar disorder is a disabling disease characterized by the recurrence of mood
episodes. Successful strategies for the acute treatment of bipolar depression are still a …

Sleep deprivation, alone or in combination with pharmacological treatment and as part of a
chronotherapy package, is of potential use for people with major depressive episodes …

Background: There are clinical as well as experimental indications that–contrary to what is
generally assumed—late partial sleep deprivation (LPSD) is not as effective as total sleep …

Objective: To provide a quantitative meta-analysis of the antidepressant effects of sleep
deprivation to complement qualitative reviews addressing response rates. Data Sources …

Backgrounds Depression is the most common mental disorder in the world. Sleep
deprivation (SD) is a well-known antidepressant. Several recombination protocols (including …

Growing clinical evidence in support of the efficacy and safety of sleep deprivation (SD), and
its biological mechanisms of action suggest that this technique can now be included among …

Objective: Therapeutic sleep deprivation (SD) is a nonpharmacological treatment that is
used most often for depression. The aim of this study was to examine the pattern of use of …

Background: Drug resistance remains a persistent source of morbidity and mortality for
patients with bipolar depression. A growing number of clinical studies support the …