Myostatin inhibits skeletal muscle development. Therefore, we sought to determine whether
larger body and muscle mass in male mice was associated with lower mRNA and protein …

Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in
skeletal muscles of adult male compared with female mice. This reduction probably occurs …

Mutations in the myostatin gene are associated with hypermuscularity, suggesting that
myostatin inhibits skeletal muscle growth. We postulated that increased tissue-specific …

Myostatin inhibits myogenesis. Therefore, we sought to determine if mice lacking the
myostatin gene [Mstn (-/-)] would lose less muscle mass than wild-type mice during 7 days of …

Constitutive myostatin gene knockout in mice causes excessive muscle growth during
development. To examine the effect of knocking out the myostatin gene after muscle has …

A human therapeutic that specifically modulates skeletal muscle growth would potentially
provide a benefit for a variety of conditions including sarcopenia, cachexia, and muscular …

Myostatin mutations in mice and cattle are associated with increased muscularity,
suggesting that myostatin is a negative regulator of skeletal muscle mass. To test the …

Myostatin is a paracrine/autocrine factor that inhibits muscle growth, and mutations that
affect myostatin activity or expression produce dramatic increases in muscle mass in several …

Previous findings have provided strong evidence that myostatin functions as a negative
regulator of muscle mass during development and growth. In the present study, we test the …

Myostatin is a negative regulator of muscle growth and fiber size. Changes in myostatin
expression might contribute to changes in muscle mass associated with various conditions …