There is widespread interest in defining factors and mechanisms that suppress the
proliferation of cancer cells. Retinoic acid (RA) is a potent suppressor of mammary cancer …

The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both
estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical …

To understand the mechanism of retinoid resistance, we studied the subcellular localization
and function of retinoid receptors in human breast cancer cell lines. Retinoid X receptor α …

Retinoic acid (RA) displays pronounced anticarcinogenic activities in several types of
cancer. Whereas the mechanisms that underlie this activity remain incompletely understood …

Retinoid X receptor (RXRα) is activated by 9-cis-retinoic acid (9cRA) and regulates
transcription as a homodimer or as a heterodimer with other nuclear receptors. We have …

In this study, we investigated the ligand-mediated regulation of retinoid X receptor (RXR) in
two human cell lines (HepG2 and JEG-3 cells), which have been reported to express RXRα …

Retinoids have been shown to inhibit the growth of a number of human tumor cells,
including several ovarian adenocarcinoma cell lines. All-trans retinoic acid (RA) is an …

All-trans-retinoic acid (trans-RA) and other retinoids exert anticancer effects through two
types of retinoid receptors, the RA receptors (RARs) and retinoid X receptors (RXRs) …

The retinoid X receptor β (RXRβ; H-2RIIBP) forms heterodimers with various nuclear
hormone receptors and binds multiple hormone response elements, including the estrogen …

Retinoid X receptors (RXRs) heterodimerize with multiple nuclear hormone receptors and
are thought to exert pleiotropic functions. To address the role of RXRs in retinoic acid-(RA) …