Atrial fibrillation (AF) is characterized by sustained high atrial activation rates and
arrhythmogenic cellular Ca2+ signaling instability; however, it is not clear how a high atrial …

During atrial fibrillation (AF) intracellular Ca2+ signaling in atrial myocytes changes
substantially. This 'remodeled'intracellular Ca2+ homeostasis plays an important role in the …

1 The cellular mechanisms governing cardiac atrial pacemaker activity are not clear. In the
present study we used perforated patch voltage clamp and confocal fluorescence …

Although atrial fibrillation (AF) is the most commonly encountered cardiac arrhythmia, the
basic mechanisms underlying this disorder remain incompletely understood. During the past …

The transient elevation of intracellular Ca2+([Ca2+] i) with each heartbeat underlies the
activation of contraction and contributes to diverse regulatory features of cellular and …

Background—Transient atrial contractile dysfunction (“atrial stunning”) follows conversion of
atrial fibrillation (AF) to sinus rhythm and has significant clinical implications; however, the …

Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …

Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …

Background: Many alterations in sarcoplasmic reticulum Ca 2+ handling proteins in atrial
myocytes have been associated with atrial fibrillation (AF) in clinical patients, whereas the …

Atrial myocytes, lacking t‐tubules, have two functionally separate groups of ryanodine
receptors (RyRs): those at the periphery colocalized with dihydropyridine receptors …