Malignant melanoma is an aggressive cancer known for its notorious resistance to most
current therapies. The basic helix-loop-helix microphthalmia transcription factor (MITF) is the …

Apoptosis and senescence are cellular failsafe programs that counteract excessive
mitogenic signaling observed in cancer cells. Melanoma is known for its notorious …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

Various environmental and genetic factors affect the development and progression of skin
cancers including melanoma. Melanoma development is initially triggered by environmental …

Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated
transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for …

The microphthalmia-associated transcription factor (MITF) is a critical regulator of
melanocyte development and differentiation. It also plays an important role in melanoma …

Microphthalmia-associated transcription factor (MITF) is the master regulator of the
melanocyte lineage. To understand how MITF regulates transcription, we used tandem …

The microphthalmia-associated transcription factor (MITF) is the “master melanocyte
transcription factor” with a complex role in melanoma. MITF protein levels vary between and …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …