Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Understanding the cancer mechanisms provides novel diagnostic, prognostic, and …

Introduction Hepatocellular carcinoma (HCC) represents a significant burden globally, which
ranks sixth among the most frequently diagnosed cancers and stands as the third leading …

Protein glycosylation is one of the most frequent and well-known posttranslational
modifications, playing important roles in physiopathological processes. Glycosylation is …

Glycosylation of cell surface proteins regulate critical cellular functions including migration,
growth, proliferation, adhesion and apoptosis. Tumorigenic cells possess gene mutations …

N-glycosylation is one of the most common types of protein modifications and it plays a vital
role in normal physiological processes. However, aberrant N-glycan modifications are …

Background Altered glycosylation associated with hepatocellular carcinoma (HCC) is well
documented. However, few reports have investigated the association between …

Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Liver cancer is the fifth most common cancer, but the second leading cause of cancer death,
in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is …

Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

Glycosylation is a well-regulated cell and microenvironment specific post-translational
modification. Several glycosyltransferases and glycosidases orchestrate the addition of …