▪ Abstract The first mouse microphthalmia transcription factor (Mitf) mutation was discovered
over 60 years ago, and since then over 24 spontaneous and induced mutations have been …

Mouse microphthalmia transcription factor (Mitf) mutations affect the development of four cell
types: melanocytes, mast cells, osteoclasts, and pigmented epithelial cells of the eye. The …

All transcription factors are equal, but some are more equal than others. In the 25 yr since
the gene encoding the microphthalmia-associated transcription factor (MITF) was first …

Microphthalmia-associated transcription factor (MITF) acts as a master regulator of
melanocyte development, function and survival by modulating various differentiation and …

The microphthalmia (mi) gene appears essential for pigment cell development and/or
survival, based on its mutation in mi mice. It has also been linked to the human disorder …

Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

The deafness–pigmentary disorder Waardenburg Syndrome Type 2 is caused by mutations
in the human Microphthalmia-associated transcription factor (MITF) gene. Multiple related …

Microphthalmia‐associated transcription factor (MITF) was initially shown to play a key role
in melanocyte differentiation through the direct transcriptional control of TYROSINASE …

Microphthalmia‐associated transcription factor (MITF) is involved in melanocyte cell
development, pigmentation and neoplasia. To determine whether MITF is somatically …

The microphthalmia-associated transcription factor (MITF) is the “master melanocyte
transcription factor” with a complex role in melanoma. MITF protein levels vary between and …