Clostridium difficile—a continually evolving and problematic pathogen

LF Dawson, E Valiente, BW Wren - Infection, Genetics and Evolution, 2009 - Elsevier
Clostridium difficile is a unique pathogen that often predominates in the bowel microflora as
a result of the microbial compositional changes following antibiotic treatment. The hospital …

Clostridium difficile: a European perspective

AM Jones, EJ Kuijper, MH Wilcox - Journal of Infection, 2013 - Elsevier
Clostridium difficile infection is the leading cause of diarrhoea in the industrialised world.
First identified in 1935, our knowledge about the clonal population structure, toxins and PCR …

Clostridium difficile: Epidemiology, Pathogenicity, and an Update on the Limitations of and Challenges in Its Diagnosis

AA Alyousef - Journal of AOAC International, 2018 - academic.oup.com
The bacterium originally named Bacillus difficilis was later renamed Clostridium difficile
because of the difficulty associated with its isolation in the laboratory. C. difficile causes …

Community-acquired Clostridium difficile infection: an increasing public health threat

A Gupta, S Khanna - Infection and drug resistance, 2014 - Taylor & Francis
There has been a startling shift in the epidemiology of Clostridium difficile infection over the
last decade worldwide, and it is now increasingly recognized as a cause of diarrhea in the …

The continually evolving Clostridium difficile species

MD Cairns, RA Stabler, N Shetty, BW Wren - Future microbiology, 2012 - Future Medicine
Clostridium difficile is a spore-forming Gram-positive bacterium that causes chronic diarrhea
and sometimes life-threatening disease mainly in elderly and hospitalized patients. The …

[HTML][HTML] Clostridium difficile–from colonization to infection

H Schaeffler, A Breitrueck - Frontiers in microbiology, 2018 - frontiersin.org
Clostridium difficile is the most frequent cause of nosocomial antibiotic-associated diarrhea.
The incidence of C. difficile infection (CDI) has been rising worldwide with subsequent …

Clostridium difficile infection

L Heinlen, JD Ballard - The American journal of the medical sciences, 2010 - Elsevier
Clostridium difficile is the leading cause of hospital-acquired diarrhea in Europe and North
America and is a serious reemerging pathogen. Recent outbreaks have led to increasing …

[引用][C] Clostridium difficile: A pathogen of the nineties

TV Riley - European Journal of Clinical Microbiology and …, 1998 - Springer
Over the last 15 years Clostridium difficile has risen from relative obscurity to be one of the
most important hospital pathogens of the 1990s. Data from the Sir Charles Gairdner Hospital …

The Changing Epidemiology of Clostridium difficile Infections

J Freeman, MP Bauer, SD Baines… - Clinical microbiology …, 2010 - Am Soc Microbiol
The epidemiology of Clostridium difficile infection (CDI) has changed dramatically during
this millennium. Infection rates have increased markedly in most countries with detailed …

Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005–2007

AK Cheknis, SP Sambol, DM Davidson, KJ Nagaro… - Anaerobe, 2009 - Elsevier
Clostridium difficile is a widely distributed pathogen with multiple strain types as determined
by restriction endonuclease analysis (REA) and by PCR ribotyping, two well-characterized …