Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

A Asakawa, A Inui, T Kaga, G Katsuura, M Fujimiya… - Gut, 2003 - gut.bmj.com
Background and aims: Ghrelin, an endogenous ligand for growth hormone secretagogue
receptor (GHS-R), is an appetite stimulatory signal from the stomach with structural …

Resistance to the orexigenic effect of ghrelin in dietary-induced obesity in mice: reversal upon weight loss

M Perreault, N Istrate, L Wang, AJ Nichols… - International journal of …, 2004 - nature.com
BACKGROUND: Ghrelin, an endogenous ligand for growth hormone secretagogue receptor
(GHS-R), is known to increase food intake in lean humans and rodents. In addition, ghrelin …

Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats

B Beck, S Richy, A Stricker-Krongrad - Life Sciences, 2004 - Elsevier
Ghrelin is a new orexigenic and adipogenic peptide primarily produced by the stomach and
the hypothalamus. In the present experiment, we determined the circulating ghrelin levels in …

Ghrelin and appetite control in humans—potential application in the treatment of obesity

M Patterson, SR Bloom, JV Gardiner - Peptides, 2011 - Elsevier
Ghrelin is a peptide hormone secreted into circulation from the stomach. It has been
postulated to act as a signal of hunger. Ghrelin administration acutely increases energy …

[HTML][HTML] The role of ghrelin in the regulation of glucose homeostasis

BN Alamri, K Shin, V Chappe, Y Anini - Hormone molecular biology …, 2016 - degruyter.com
Ghrelin is a 28-amino acid (aa) stomach-derived peptide discovered in 1999 as the
endogenous ligand for growth hormone secretagogue-receptor (GHS-R). Ghrelin-producing …

Circulating ghrelin levels are decreased in human obesity

M Tschop, C Weyer, PA Tataranni, V Devanarayan… - Diabetes, 2001 - Am Diabetes Assoc
Ghrelin is a novel endogenous natural ligand for the growth hormone (GH) secretagogue
receptor that has recently been isolated from the rat stomach. Ghrelin administration …

Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin

A Asakawa, A Inui, O Kaga, H Yuzuriha, T Nagata… - Gastroenterology, 2001 - Elsevier
Background & Aims: Ghrelin, an endogenous ligand for growth hormone secretagogue
receptor, was recently identified in the rat stomach. We examined the effects of the gastric …

Effects of high-fat feeding and fasting on ghrelin expression in the mouse stomach

SG Moesgaard, B Ahrén, RD Carr, DX Gram… - Regulatory peptides, 2004 - Elsevier
Ghrelin is a peptide identified as an endogenous ligand for the growth hormone
secretagogue receptor. Studies have shown that ghrelin stimulates growth hormone …

Upregulation of ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration

K Toshinai, MS Mondal, M Nakazato, Y Date… - Biochemical and …, 2001 - Elsevier
Ghrelin is a novel gut–brain peptide that binds to the growth hormone secretagogue
receptor (GHS-R), thereby functioning in the regulation of growth hormone (GH) release and …

Ghrelin increases food intake in obese as well as lean subjects

MR Druce, AM Wren, AJ Park, JE Milton… - International journal of …, 2005 - nature.com
OBJECTIVE: To investigate whether effects on food intake are seen in obese subjects
receiving exogenous administration of ghrelin. DESIGN: Randomised, double-blind …