The benefits of hypothermic machine preservation and short cold ischemia times in deceased donor kidneys

J Kox, C Moers, D Monbaliu, A Strelniece… - …, 2018 - journals.lww.com
Background Hypothermic machine perfusion (HMP) of deceased donor kidneys is
associated with better outcome when compared to static cold storage (CS). Nevertheless …

Normothermic machine perfusion systems: where do we go from here?

S López-Martínez, C Simón, X Santamaria - Transplantation, 2024 - journals.lww.com
Normothermic machine perfusion (NMP) aims to preserve organs ex vivo by simulating
physiological conditions such as body temperature. Recent advancements in NMP system …

[HTML][HTML] Renal normothermic machine perfusion: the road toward clinical implementation of a promising pretransplant organ assessment tool

TL Hamelink, B Ogurlu, J De Beule, VA Lantinga… - …, 2022 - journals.lww.com
The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

The future of organ perfusion and re‐conditioning

A Weissenbacher, G Vrakas, D Nasralla… - Transplant …, 2019 - Wiley Online Library
Organ preservation and re‐conditioning using machine perfusion technologies continue to
generate promising results in terms of viability assessment, organ utilization and improved …

[HTML][HTML] Protocol of a randomised controlled, open-label trial of ex vivo normothermic perfusion versus static cold storage in donation after circulatory death renal …

SA Hosgood, K Saeb-Parsy, C Wilson, C Callaghan… - BMJ open, 2017 - bmjopen.bmj.com
Introduction Ex vivo normothermic perfusion (EVNP) is a novel technique that reconditions
the kidney and restores renal function prior to transplantation. Phase I data from a series of …

Maximizing organs for donation: the potential for ex situ normothermic machine perfusion

C Griffiths, WE Scott III, S Ali… - QJM: An International …, 2023 - academic.oup.com
Currently, there is a shortfall in the number of suitable organs available for transplant
resulting in a high number of patients on the active transplant waiting lists worldwide. To …

[HTML][HTML] Red blood cells as oxygen carrier during normothermic machine perfusion of kidney grafts: Friend or foe?

AS Arykbaeva, LJS Lerink, J Vos, MA Engelse… - American Journal of …, 2024 - Elsevier
Renal ex vivo normothermic machine perfusion (NMP) is under development as an
assessment tool for high-risk kidney grafts and as a means of achieving more …

Development of a prolonged warm ex vivo perfusion model for kidneys donated after cardiac death

D Urcuyo, MF Blum, Q Liu, A Nassar… - … Journal of Artificial …, 2017 - journals.sagepub.com
Purpose Ex vivo perfusion of marginal kidney grafts offers the chance to expand the donor
pool, but there is no current clinical standard for the prolonged warm perfusion of renal …

Hypothermic machine perfusion in deceased donor kidney transplantation: a systematic review

VWT Lam, JM Laurence, AJ Richardson… - Journal of Surgical …, 2013 - Elsevier
BACKGROUND: Hypothermic machine perfusion (HMP) of kidneys is intended to mitigate
the deleterious effects of cold storage on organ quality, particularly when the cold ischemic …

Eight-hour continuous normothermic ex vivo kidney perfusion is a safe preservation technique for kidney transplantation: a new opportunity for the storage …

JM Kaths, J Echeverri, N Goldaracena, KS Louis… - …, 2016 - journals.lww.com
Background Hypothermic kidney storage causes preservation injury and is poorly tolerated
by renal grafts. We investigated whether static cold storage (SCS) can be safely replaced …